广东化工
廣東化工
엄동화공
GUANGDONG CHEMICAL INDUSTRY
2013年
8期
31
,共1页
S-那氟沙星%拆分%精制
S-那氟沙星%拆分%精製
S-나불사성%탁분%정제
S-Nadifoxacin%resolution%refined
本篇文章报道了那氟沙星关键中间体5,6-二氟-2-甲基-1,2,3,4-四氢喹啉的高效手性拆分方法,手性纯度达到99.5%以上,收率42%以上,本工艺反应条件平和,已经实现了产业化生产.
本篇文章報道瞭那氟沙星關鍵中間體5,6-二氟-2-甲基-1,2,3,4-四氫喹啉的高效手性拆分方法,手性純度達到99.5%以上,收率42%以上,本工藝反應條件平和,已經實現瞭產業化生產.
본편문장보도료나불사성관건중간체5,6-이불-2-갑기-1,2,3,4-사경규람적고효수성탁분방법,수성순도체도99.5%이상,수솔42%이상,본공예반응조건평화,이경실현료산업화생산.
The paper described an efficient method for the chiral resolution of 5,6-difluoro-2-methyl-1,2,3,4-Tetrahydroquinoline, which was the key intermediates of nadifloxacin. The chiral purity was up to 99.5 %, the yield was above 42 %. The reaction condition is gentle and the industrialization of the production was achieved.
