广东化工
廣東化工
엄동화공
GUANGDONG CHEMICAL INDUSTRY
2013年
8期
42
,共1页
雷晶晶%柴慧芳*%赵春深%董磊%曾晓萍
雷晶晶%柴慧芳*%趙春深%董磊%曾曉萍
뢰정정%시혜방*%조춘심%동뢰%증효평
2,6-二氯-4-甲基烟腈%乙酰乙酸乙酯%氰乙酰胺%改进
2,6-二氯-4-甲基煙腈%乙酰乙痠乙酯%氰乙酰胺%改進
2,6-이록-4-갑기연정%을선을산을지%청을선알%개진
2,6-dichloro-4-methylnicotinonitrile%Ethyl acetoacetate%cyanoacetamide%improvement
介绍了标题化合物的合成路线的改进.以乙酰乙酸乙酯和氰乙酰胺为原料,经过环合、氯代两步反应得到目标产物,并经 MS 和1HNMR 对其结构进行了表征.本合成路线反应条件温和,操作方便,收率较高,适合工业化生产.反应总收率80.3%.
介紹瞭標題化閤物的閤成路線的改進.以乙酰乙痠乙酯和氰乙酰胺為原料,經過環閤、氯代兩步反應得到目標產物,併經 MS 和1HNMR 對其結構進行瞭錶徵.本閤成路線反應條件溫和,操作方便,收率較高,適閤工業化生產.反應總收率80.3%.
개소료표제화합물적합성로선적개진.이을선을산을지화청을선알위원료,경과배합、록대량보반응득도목표산물,병경 MS 화1HNMR 대기결구진행료표정.본합성로선반응조건온화,조작방편,수솔교고,괄합공업화생산.반응총수솔80.3%.
In the paper, we introduced a approach to synthetize the title compound, was realized and manufactured from ethyl acetoacetate and cyanoacetamide via two steps, including cyclization and chlorination. Its structure was verified by MS and 1H NMR. This synthetic route has the advantages of convenient operation and mild reaction conditions. The total product yield was 80.3 %. This program is suitable for industrial production.
