CAJ | 학술논문

背景:阿尔茨海默病的病因涉及遗传、环境、免疫等多种因素和机制,大量研究表明Wnt信号通路与之密切相关,也有研究表明,Wnt信号通路对神经干细胞的增殖发挥着决定性作用.目的:对阿尔茨海默病的病理过程与Wnt 信号通路的关系以及 Wnt 信号通路与神经干细胞增殖分化进行综述,为阿尔茨海默病的治疗提供理论依据.方法:通过Pubmed数据库检索有关阿尔茨海默病病理过程与Wnt信号通路及Wnt信号通路与神经干细胞关联的相关文献,检索词为“Alzheimer’s disease、Wnt signaling pathway、NSCs、stem cel differentiation、amyloid-βprotein、Protein Tau”.纳入与阿尔茨海默病和Wnt信号通路相关的文献,排除重复性研究,保留50篇文献进行综述.结果与结论:目前通过神经干细胞移植来治疗以神经元的缺失为特征的神经退行性疾病已成为研究的热点,而如何调控神经干细胞向特定神经元分化成为了研究的难点,信号转导在神经干细胞的分化中起重要的作用,其中Wnt信号通路是调节神经干细胞增殖及分化的细胞外的重要因素.Wnt信号通路的失活可以促进阿尔茨海默病的病理过程,相反激活Wnt信号通路可以保护海马神经元,同时促进神经干细胞的分化,为阿尔茨海默病的治疗提供新的思路.
배경:아이자해묵병적병인섭급유전、배경、면역등다충인소화궤제,대량연구표명Wnt신호통로여지밀절상관,야유연구표명,Wnt신호통로대신경간세포적증식발휘착결정성작용.목적:대아이자해묵병적병리과정여Wnt 신호통로적관계이급 Wnt 신호통로여신경간세포증식분화진행종술,위아이자해묵병적치료제공이론의거.방법:통과Pubmed수거고검색유관아이자해묵병병리과정여Wnt신호통로급Wnt신호통로여신경간세포관련적상관문헌,검색사위“Alzheimer’s disease、Wnt signaling pathway、NSCs、stem cel differentiation、amyloid-βprotein、Protein Tau”.납입여아이자해묵병화Wnt신호통로상관적문헌,배제중복성연구,보류50편문헌진행종술.결과여결론:목전통과신경간세포이식래치료이신경원적결실위특정적신경퇴행성질병이성위연구적열점,이여하조공신경간세포향특정신경원분화성위료연구적난점,신호전도재신경간세포적분화중기중요적작용,기중Wnt신호통로시조절신경간세포증식급분화적세포외적중요인소.Wnt신호통로적실활가이촉진아이자해묵병적병리과정,상반격활Wnt신호통로가이보호해마신경원,동시촉진신경간세포적분화,위아이자해묵병적치료제공신적사로.
BACKGROUND:The pathological mechanism of Alzheimer’s disease involves inherited, environmental and immunological factors. Strong evidence exists that Wnt signaling pathway is closely related to the pathological process of Alzheimer’s disease. There is also evidence that Wnt signaling pathway plays a crucial effect on the proliferation of neural stem cel s. OBJECTIVE:To review the relationship between pathological process of Alzheimer’s disease and Wnt signaling pathway and effects of Wnt signaling on proliferation and differentiation of neural stem cel s, providing theoretical evidence for treatment of Alzheimer’s disease. METHODS:A computer-based online search of PubMed databases was undertaken for papers addressing the relationship of Alzheimer’s disease and Wnt signaling pathway and the correlation between Wnt signaling pathway and neural stem cel s using the key words“Alzheimer’s disease, Wnt signaling pathway, NSCs, stem cel differentiation, amyloid-βprotein, protein Tau”. After excluding papers with repetitive contents, 50 papers were suitable for final analysis. RESULTS AND CONCLUSION:Treatment of neurodegenerative diseases characterized by neuron loss using neural stem cel transplantation has become a gradual y increased research area. However, how to regulate neural stem cel s to differentiate into specific neurons has been proposed. Signal transduction plays an important role in the differentiation of neural stem cel s and Wnt signaling pathway is an important extracel ular factor of regulating the proliferation and differentiation of neural stem cel s. Inactivation of Wnt signaling pathway promotes the progression of Alzheimer’s disease, and activation of Wnt signaling pathway protects hippocampal neurons and promotes the differentiation of neural stem cel s. This may provide novel therapeutic methods for Alzheimer’s disease.