CAJ | 학술논문

目的:探讨 Ang Ⅱ、Ang(1-7)在肾病综合症(肾综)患者中的表达及其可能的相互作用机制.方法:实验设正常对照组和肾综组,采用 ELISA法测定血浆中 Ang Ⅱ、Ang(1-7)浓度.结果:1、肾综组、正常组血浆中 Ang Ⅱ浓度分别为:(129.137±29.518)pg/mL、(102.267±25.787)pg/mL,(t=-3.762,P﹤0.01);肾综组、正常组血浆中 Ang(1-7)浓度分别为:(104.7±24.548)pg/mL、(80.339±18.376)pg/mL,(t=-4.394,P﹤0.01).正常组中,Ang(1-7)与 Ang Ⅱ在肾综组中的表达呈线性相关(r=0.678,P﹤0.01);肾综组中,血浆 Ang(1-7)与 Ang Ⅱ浓度呈线性相关(r=0.902,P﹤0.01);2、肾综组中,Ang Ⅱ、Ang(1-7)均与血浆 Ca2+浓度、尿素氮、肌酐、24小时尿蛋白含量无显著性差异(P 值均>0.05);3、肾综组中,正常血压患者与临界高血压患者血浆 Ang Ⅱ浓度之间无显著性统计学差异(t=-2.44,P>0.05);正常血压患者与临界高血压患者血浆 Ang(1-7)浓度无显著统计学差异(t=0.317,P>0.05).结论:Ang Ⅱ、Ang(1-7)共同参与了肾综的发病机制,Ang(1-7)对 Ang Ⅱ具有拮抗作用,对肾脏具有保护作用.
목적:탐토 Ang Ⅱ、Ang(1-7)재신병종합증(신종)환자중적표체급기가능적상호작용궤제.방법:실험설정상대조조화신종조,채용 ELISA법측정혈장중 Ang Ⅱ、Ang(1-7)농도.결과:1、신종조、정상조혈장중 Ang Ⅱ농도분별위:(129.137±29.518)pg/mL、(102.267±25.787)pg/mL,(t=-3.762,P﹤0.01);신종조、정상조혈장중 Ang(1-7)농도분별위:(104.7±24.548)pg/mL、(80.339±18.376)pg/mL,(t=-4.394,P﹤0.01).정상조중,Ang(1-7)여 Ang Ⅱ재신종조중적표체정선성상관(r=0.678,P﹤0.01);신종조중,혈장 Ang(1-7)여 Ang Ⅱ농도정선성상관(r=0.902,P﹤0.01);2、신종조중,Ang Ⅱ、Ang(1-7)균여혈장 Ca2+농도、뇨소담、기항、24소시뇨단백함량무현저성차이(P 치균>0.05);3、신종조중,정상혈압환자여림계고혈압환자혈장 Ang Ⅱ농도지간무현저성통계학차이(t=-2.44,P>0.05);정상혈압환자여림계고혈압환자혈장 Ang(1-7)농도무현저통계학차이(t=0.317,P>0.05).결론:Ang Ⅱ、Ang(1-7)공동삼여료신종적발병궤제,Ang(1-7)대 Ang Ⅱ구유길항작용,대신장구유보호작용.