医药前沿
醫藥前沿
의약전연
YIAYAO QIANYAN
2013年
11期
80-81
,共2页
类风湿关节炎%抗CCP抗体%动脉粥样硬化%骨侵蚀
類風濕關節炎%抗CCP抗體%動脈粥樣硬化%骨侵蝕
류풍습관절염%항CCP항체%동맥죽양경화%골침식
rheumatoid arthritis%anti-CCP antibody%atherosclerosis%bone erosion
目的探讨抗 CCP 抗体在类风湿关节炎(Rheumatoid arthritis,RA)中的诊断价值,抗 CCP 抗体与动脉粥样硬化及骨侵蚀的关系.方法利用 Elasa 法检测 RA 患者及健康对照组的抗 CCP 抗体,高分辨率超声测量 RA 及健康对照组的颈动脉内膜中层厚度(Carotid artery intimamedia thickness,IMT),分析抗 CCP 抗体在RA 诊断中的敏感性及特异性,RA 患者的颈动脉粥样硬化情况.X 线评估 RA 患者双手关节的骨侵蚀情况,根据抗 CCP 抗体是否阳性将 RA 患者分为两组,抗 CCP抗体阳性组和抗 CCP 抗体阴性组,比较两组的颈动脉粥样硬化及骨侵蚀发生率.结果抗 CCP 抗体诊断 RA 的敏感性75%,特异性90%.与健康对照组相比,RA患者的颈动脉内膜中层厚度增加(P <0.05),动脉粥样硬化率增加(X2=5.19,P <0.05).在 RA 患者中,与抗 CCP 抗体阴性组比较,抗 CCP 抗体阳性组的颈动脉内膜中层厚度增加(P <0.05),动脉粥样硬化率增加(X2=5.6,P <0.05),骨侵蚀率增加(X2=7.35,P <0.05).结论抗 CCP 抗体阳性的 RA 患者更易发生动脉粥样硬化及骨侵蚀.
目的探討抗 CCP 抗體在類風濕關節炎(Rheumatoid arthritis,RA)中的診斷價值,抗 CCP 抗體與動脈粥樣硬化及骨侵蝕的關繫.方法利用 Elasa 法檢測 RA 患者及健康對照組的抗 CCP 抗體,高分辨率超聲測量 RA 及健康對照組的頸動脈內膜中層厚度(Carotid artery intimamedia thickness,IMT),分析抗 CCP 抗體在RA 診斷中的敏感性及特異性,RA 患者的頸動脈粥樣硬化情況.X 線評估 RA 患者雙手關節的骨侵蝕情況,根據抗 CCP 抗體是否暘性將 RA 患者分為兩組,抗 CCP抗體暘性組和抗 CCP 抗體陰性組,比較兩組的頸動脈粥樣硬化及骨侵蝕髮生率.結果抗 CCP 抗體診斷 RA 的敏感性75%,特異性90%.與健康對照組相比,RA患者的頸動脈內膜中層厚度增加(P <0.05),動脈粥樣硬化率增加(X2=5.19,P <0.05).在 RA 患者中,與抗 CCP 抗體陰性組比較,抗 CCP 抗體暘性組的頸動脈內膜中層厚度增加(P <0.05),動脈粥樣硬化率增加(X2=5.6,P <0.05),骨侵蝕率增加(X2=7.35,P <0.05).結論抗 CCP 抗體暘性的 RA 患者更易髮生動脈粥樣硬化及骨侵蝕.
목적탐토항 CCP 항체재류풍습관절염(Rheumatoid arthritis,RA)중적진단개치,항 CCP 항체여동맥죽양경화급골침식적관계.방법이용 Elasa 법검측 RA 환자급건강대조조적항 CCP 항체,고분변솔초성측량 RA 급건강대조조적경동맥내막중층후도(Carotid artery intimamedia thickness,IMT),분석항 CCP 항체재RA 진단중적민감성급특이성,RA 환자적경동맥죽양경화정황.X 선평고 RA 환자쌍수관절적골침식정황,근거항 CCP 항체시부양성장 RA 환자분위량조,항 CCP항체양성조화항 CCP 항체음성조,비교량조적경동맥죽양경화급골침식발생솔.결과항 CCP 항체진단 RA 적민감성75%,특이성90%.여건강대조조상비,RA환자적경동맥내막중층후도증가(P <0.05),동맥죽양경화솔증가(X2=5.19,P <0.05).재 RA 환자중,여항 CCP 항체음성조비교,항 CCP 항체양성조적경동맥내막중층후도증가(P <0.05),동맥죽양경화솔증가(X2=5.6,P <0.05),골침식솔증가(X2=7.35,P <0.05).결론항 CCP 항체양성적 RA 환자경역발생동맥죽양경화급골침식.
Objective To investigate the diagnostic value of anti-cyclic citrulinated peptide(CCP) antibody in Rheumatoid arthritis (RA) and the relationship between anti-CCP antibody with atherosclerosis and bone erosion. Methods To detection anti- CCP antibody titer of RA patients and healthy control group by using the method of Elasa, measure carotid artery intima-media thickness (IMT) of RA and healthy control group by high resolution ultrasound. To analysis the sensitivity and specificity of anti- CCP antibody in the diagnosis of RA, carotid atherosclerosis in RA patients. X-ray evaluation bone erosion of hands joint in RA patients. according to whether anti-CCP antibody was positive, the patients with RA were divided into two groups, anti-CCP antibody positive group and anti-CCP antibody negative group, compared the incidence of carotid atherosclerosis and bone erosion of two groups. Results the sensitivity of anti-CCP antibody in the diagnosis of RA was 75%, the specificity was 90%. Compared with the healthy control group, the carotid artery intima-media thickness in patients with RA increased (P ﹤ 0.05), atherosclerosis rate increased (X2=5.19, P ﹤ 0.05). In RA patients, Compared with anti-CCP antibody negative group, carotid artery intima-media thickness of positive group increased (P ﹤ 0.05), atherosclerosis rate increased (X2=5.6, P ﹤ 0.05), bone erosion rate increased (X2=7.35, P ﹤ 0.05). Conclusion RA patients with positive anti-CCP antibody are more susceptible to atherosclerosis and bone erosion.
