医药前沿
醫藥前沿
의약전연
YIAYAO QIANYAN
2013年
11期
108-109
,共2页
王乐朋%胡福英%侯莉莉%王鸿程
王樂朋%鬍福英%侯莉莉%王鴻程
왕악붕%호복영%후리리%왕홍정
STAT5%WWOX%c-myc%非小细胞肺癌
STAT5%WWOX%c-myc%非小細胞肺癌
STAT5%WWOX%c-myc%비소세포폐암
NSCLC%STAT5%c-myc%wwox
目的:探讨信号转导和转录激活因子-5(Signal transducer and activator of transcripton 5,STAT5)、WW 结构域氧化还原酶基因(WW domain-containing oxidoreductase,WWOX)和 c-myc 蛋白在非小细胞肺癌(non smal cel lung cancer,NSCLC)中的表达及相关性研究.方法:用免疫组化 SP 法检测40例手术切除的 NSCLC组织和20例正常肺组织中 STAT5、WWOX 和 c-myc 的蛋白表达.结果:STAT5和 c-myc 蛋白在 NSCLC 中的表达明显高于正常肺组织,而 WWOX 在 NSCLC 中的表达明显低于正常肺组织(P﹤0.01);STAT5、c-myc 表达水平与 NSCLC 组织学类型有关,在腺癌组织中的表达明显高于鳞癌(P﹤0.01), WWOX 基因的表达与淋巴结转移相关,有淋巴结转移的表达低于无淋巴结结转移(P﹤0.05);STAT5蛋白和 wwox 蛋白在 NSCLC 组织中的表达呈负相关(P﹤0.05),而 STAT5和 c-myc 的表达、WWOX 与 c-myc 的表达无相关性(P >0.05).结论:在 NSCLC 中存在 STAT5和 c-myc 的过度表达以及 WWOX 的失表达,STAT5、c-myc 表达水平与 NSCLC 组织学类型有关,而 WWOX 的表达与淋巴结转移相关.在 NSCLC 的发生机制中,提示 WWOX 可能通过抑制 STATs 系统,促进细胞凋亡,起到抑癌作用.
目的:探討信號轉導和轉錄激活因子-5(Signal transducer and activator of transcripton 5,STAT5)、WW 結構域氧化還原酶基因(WW domain-containing oxidoreductase,WWOX)和 c-myc 蛋白在非小細胞肺癌(non smal cel lung cancer,NSCLC)中的錶達及相關性研究.方法:用免疫組化 SP 法檢測40例手術切除的 NSCLC組織和20例正常肺組織中 STAT5、WWOX 和 c-myc 的蛋白錶達.結果:STAT5和 c-myc 蛋白在 NSCLC 中的錶達明顯高于正常肺組織,而 WWOX 在 NSCLC 中的錶達明顯低于正常肺組織(P﹤0.01);STAT5、c-myc 錶達水平與 NSCLC 組織學類型有關,在腺癌組織中的錶達明顯高于鱗癌(P﹤0.01), WWOX 基因的錶達與淋巴結轉移相關,有淋巴結轉移的錶達低于無淋巴結結轉移(P﹤0.05);STAT5蛋白和 wwox 蛋白在 NSCLC 組織中的錶達呈負相關(P﹤0.05),而 STAT5和 c-myc 的錶達、WWOX 與 c-myc 的錶達無相關性(P >0.05).結論:在 NSCLC 中存在 STAT5和 c-myc 的過度錶達以及 WWOX 的失錶達,STAT5、c-myc 錶達水平與 NSCLC 組織學類型有關,而 WWOX 的錶達與淋巴結轉移相關.在 NSCLC 的髮生機製中,提示 WWOX 可能通過抑製 STATs 繫統,促進細胞凋亡,起到抑癌作用.
목적:탐토신호전도화전록격활인자-5(Signal transducer and activator of transcripton 5,STAT5)、WW 결구역양화환원매기인(WW domain-containing oxidoreductase,WWOX)화 c-myc 단백재비소세포폐암(non smal cel lung cancer,NSCLC)중적표체급상관성연구.방법:용면역조화 SP 법검측40례수술절제적 NSCLC조직화20례정상폐조직중 STAT5、WWOX 화 c-myc 적단백표체.결과:STAT5화 c-myc 단백재 NSCLC 중적표체명현고우정상폐조직,이 WWOX 재 NSCLC 중적표체명현저우정상폐조직(P﹤0.01);STAT5、c-myc 표체수평여 NSCLC 조직학류형유관,재선암조직중적표체명현고우린암(P﹤0.01), WWOX 기인적표체여림파결전이상관,유림파결전이적표체저우무림파결결전이(P﹤0.05);STAT5단백화 wwox 단백재 NSCLC 조직중적표체정부상관(P﹤0.05),이 STAT5화 c-myc 적표체、WWOX 여 c-myc 적표체무상관성(P >0.05).결론:재 NSCLC 중존재 STAT5화 c-myc 적과도표체이급 WWOX 적실표체,STAT5、c-myc 표체수평여 NSCLC 조직학류형유관,이 WWOX 적표체여림파결전이상관.재 NSCLC 적발생궤제중,제시 WWOX 가능통과억제 STATs 계통,촉진세포조망,기도억암작용.
Objective:To investigate the expression of STAT5 ,WWOX and c-myc in non smal cel lung cancer(NSCLC) and their clinical significance. Method: Forty resected tissue samples from patients with NSCLC and twenty normal lung tissues were subjected to immunohistochemical staining(SP) for STAT5 ,WWOX and c-myc. Results: The expression of STAT5 and c-myc is apparently rised and the expression of wwox is apparently lower in NSCLC than these in normal lung tissues, this has a significance (P﹤0.01). The expression of STAT5and c-myc are concerned with NSCLC histological types, in adenocarcinoma was significantly higher than squamous cel carcinoma (P ﹤0.01); WWOX gene expression and whether there is lymph node metastasis , with lymph node metastasis NSCLC loss of WWOX gene expression or express a more reduced(P﹤0.05). There was a negative correlation between the expressions of STAT5 and WWOX.But no relationship was found between STAT5 and c-myc or WWOX and c-myc (P > 0.05). Conclusion: STAT5 and c-myc expression rised in NSCLC was significantly than in normal lung tissue, and similarly, WWOX in NSCLC tissue was low, and its expression in the absence or reduction of tumor invasion may be related. STAT5, c-myc expression are concerned with the NSCLC histological types;WWOX gene expression is concerned with whether the lymph node metastasis, loss or reduction of its expression with tumor aggressiveness. WWOX expression was negatively related to the higher expression of STAT5 in NSCLC. In the generate mechanism of the NSCLC ,it prompt that WWOX might pass to refrain STATs,to advance apoptosis and to restrain the NSCLC.
