CAJ | 학술논문

目的探讨干扰素联α1b合炎琥宁治疗手足口病的临床疗效.方法68例手足口病随机分为对照组和治疗组各34例,在常规给予维生素、对症治疗基础上,对照组给予炎琥宁10㎎/㎏静脉滴注,1次/d;治疗组给予干扰素α1b5万IU/(㎏?d)肌肉注射,加炎琥宁10㎎/㎏静脉滴注,1次/d.结果治疗组在平均退热时间、皮疹消退时间及住院时间均优于对照组;治疗组总有效率97.0%,对照组总有效率79.4%,两组比较差异有统计学意义(P<0.01).结论干扰素α1b联合炎琥宁治疗手足口病的临床疗效显著,无明显不良反应,值得儿科临床推广使用.
목적탐토간우소련α1b합염호저치료수족구병적림상료효.방법68례수족구병수궤분위대조조화치료조각34례,재상규급여유생소、대증치료기출상,대조조급여염호저10㎎/㎏정맥적주,1차/d;치료조급여간우소α1b5만IU/(㎏?d)기육주사,가염호저10㎎/㎏정맥적주,1차/d.결과치료조재평균퇴열시간、피진소퇴시간급주원시간균우우대조조;치료조총유효솔97.0%,대조조총유효솔79.4%,량조비교차이유통계학의의(P<0.01).결론간우소α1b연합염호저치료수족구병적림상료효현저,무명현불량반응,치득인과림상추엄사용.
Objective to investigate the therapeutic effect of interferon combined with Yanhuning for children with hand, foot and mouth disease. Methods 68 cases of hand, foot and mouth disease patients were randomized into control and therapy group. Both group were treated with vitamins, the control group received Yanhuning 10㎎/㎏ intravenous infusion, once daily; the treatment group received interferon 50,000IU/(kg?d)intramuscular injection and Yanhuning 10㎎/㎏ intravenous infusion, once daily. Results The total effective rate of the treatment group was 94.1%, while that of the control group was 79.4%. The difference between the two groups was significant (P<0.01).The average cooling time, the rash subsided time and the hospitalization time in treatment group were significantly shorter than those of the control group. Conclusions the therapy of interferon combined with Yanhuning is effect for children with hand, foot and mouth disease, and worthy of clinical use.