中国男科学杂志
中國男科學雜誌
중국남과학잡지
CHINESE JOURNAL OF ANDROLOGY
2013年
4期
30-33
,共4页
吴卓%徐计秀*%王璟琦%吉鹏%智二磊
吳卓%徐計秀*%王璟琦%吉鵬%智二磊
오탁%서계수*%왕경기%길붕%지이뢰
解脲支原体%沙眼衣原体%不育%男性%病例对照研究%Meta分析
解脲支原體%沙眼衣原體%不育%男性%病例對照研究%Meta分析
해뇨지원체%사안의원체%불육%남성%병례대조연구%Meta분석
ureaplasma urealyticum%chlamydia trachomatis%infertility, male%case control study%meta analysis
目的采用Meta分析的方法探讨解脲支原体、沙眼衣原体感染与男性不育的关系.方法采用计算机检索和手工检索相结合的方法,检索2011年12月以前的PUBMED, EMBASE,Cochrane图书馆,CNKI,CBMdisc等国内外数据库,查找解脲支原体、沙眼衣原体感染与男性不育关系的病例对照研究.由两位研究者按照纳入与排除标准进行资料提取和质量评价后,采用RevMan 5.0软件对各研究进行数据合并与分析.结果(1)共纳入5个符合要求的病例对照研究,共包括1068例患者;(2)对所纳入的研究进行质量评分,结果质量均4分.(3)单纯解脲支原体感染OR合并值为3.29[95%CI(2.24,4.82),P<0.00001],两组差别有统计学意义;(4)单纯沙眼衣原体感染OR合并值为3.43[95%CI(1.92,6.14),P<0.0001],两组差别有统计学意义;(5)解脲支原体合并沙眼衣原体感染OR合并值为4.64[95%CI(1.90,11.37),P=0.0008],两组差别有统计学意义;结论无论是解脲支原体感染,还是沙眼衣原体感染都是影响男性不育的显著危险因素,而当两者合并感染时更易导致男性不育.由于纳入的研究存在选择性偏倚和发表性偏倚的可能性.期待更多进行高质量的相关对照试验,以提供坚实、可靠的证据.
目的採用Meta分析的方法探討解脲支原體、沙眼衣原體感染與男性不育的關繫.方法採用計算機檢索和手工檢索相結閤的方法,檢索2011年12月以前的PUBMED, EMBASE,Cochrane圖書館,CNKI,CBMdisc等國內外數據庫,查找解脲支原體、沙眼衣原體感染與男性不育關繫的病例對照研究.由兩位研究者按照納入與排除標準進行資料提取和質量評價後,採用RevMan 5.0軟件對各研究進行數據閤併與分析.結果(1)共納入5箇符閤要求的病例對照研究,共包括1068例患者;(2)對所納入的研究進行質量評分,結果質量均4分.(3)單純解脲支原體感染OR閤併值為3.29[95%CI(2.24,4.82),P<0.00001],兩組差彆有統計學意義;(4)單純沙眼衣原體感染OR閤併值為3.43[95%CI(1.92,6.14),P<0.0001],兩組差彆有統計學意義;(5)解脲支原體閤併沙眼衣原體感染OR閤併值為4.64[95%CI(1.90,11.37),P=0.0008],兩組差彆有統計學意義;結論無論是解脲支原體感染,還是沙眼衣原體感染都是影響男性不育的顯著危險因素,而噹兩者閤併感染時更易導緻男性不育.由于納入的研究存在選擇性偏倚和髮錶性偏倚的可能性.期待更多進行高質量的相關對照試驗,以提供堅實、可靠的證據.
목적채용Meta분석적방법탐토해뇨지원체、사안의원체감염여남성불육적관계.방법채용계산궤검색화수공검색상결합적방법,검색2011년12월이전적PUBMED, EMBASE,Cochrane도서관,CNKI,CBMdisc등국내외수거고,사조해뇨지원체、사안의원체감염여남성불육관계적병례대조연구.유량위연구자안조납입여배제표준진행자료제취화질량평개후,채용RevMan 5.0연건대각연구진행수거합병여분석.결과(1)공납입5개부합요구적병례대조연구,공포괄1068례환자;(2)대소납입적연구진행질량평분,결과질량균4분.(3)단순해뇨지원체감염OR합병치위3.29[95%CI(2.24,4.82),P<0.00001],량조차별유통계학의의;(4)단순사안의원체감염OR합병치위3.43[95%CI(1.92,6.14),P<0.0001],량조차별유통계학의의;(5)해뇨지원체합병사안의원체감염OR합병치위4.64[95%CI(1.90,11.37),P=0.0008],량조차별유통계학의의;결론무론시해뇨지원체감염,환시사안의원체감염도시영향남성불육적현저위험인소,이당량자합병감염시경역도치남성불육.유우납입적연구존재선택성편의화발표성편의적가능성.기대경다진행고질량적상관대조시험,이제공견실、가고적증거.
@@@@Objective To analyze the correlation of Ureaplasma urealyticum and Chlamydia trachomatis infections with male sterility. Methods Pubmed, EMBASE, The Cochrane Library, CNKI and CBMdisc were searched from the date of their establishment to Dec. 2011 to collect the case control studies on the relationship between Ureaplasma urealyticum and Chlamydia trachomatis infections with male sterility.Two researchers independently selected studies, extracted data and assessed thequality according to the inclusive and exclusive criteria, and then conducted Meta-analyses by using RevMan5.0 soft ware for heterogeneity test and pooled OR calculation. Results Five case control studies involving 1068 patients were included. The quality of all studies scored 4, indicating reliable quality.Meta analyses of the Ureaplasma urealyticum, Chlamydia trachomatis, Ureaplasma urealyticum and Chlamydia trachomatis were OR(95%CI) values were 3.29 (2.24-4.82), P<0.00001;OR(95%CI)values were 3.43 (1.92-6.14),P<0.0001; OR (95%CI)values were 4.64 (1.90-11.37), P=0.0008, respectively.Irritation sign of all of two group difference had significance statistically. Conclusion Whether Ureaplasma urealyticum infection, or chlamydia trachomatis infection were all significant risk factors for male sterility, and when both merge infection more likely to lead to male sterility. Owing to high possibility of selection bias and publication bias in included studies ,high quality evidences form high quality case control study need to be further provided.
