CAJ | 학술논문

目的:探讨血清细胞间粘附分子-1和白细胞介素-6表达与肾功能损害的相关性,用以评价血清ICAM-1和IL-6浓度检测用于评价肾功能损伤中的临床价值.方法:选择2011年8月-2012年7月来本院接受肾功能损伤检查的48例患者为研究对象.采用ELISA检测血清ICAM-1和IL-6浓度,采用半自动生化分析仪检测血清肌酐浓度并计算肾小球滤过率(eGFR)值.比较eGFR≥90组和eGFR<90组血清ICAM-1和IL-6浓度,并分析血清ICAM-1和IL-6浓度与eGFR的相关性.结果:eGFR<90组(肾功能损伤组)血清ICAM-1和IL-6浓度均显著高于eGFR≥90组(肾功能正常组)(P<0.05).血清ICAM-1和IL-6浓度与eGFR呈显著地负相关性(r=-0.9283, P=0.013;r=-0.9369,P=0.001).结论:血清ICAM-1和IL-6可能与肾功能损伤有关,且其浓度检测具有评价肾功能异常的潜在临床价值.
목적:탐토혈청세포간점부분자-1화백세포개소-6표체여신공능손해적상관성,용이평개혈청ICAM-1화IL-6농도검측용우평개신공능손상중적림상개치.방법:선택2011년8월-2012년7월래본원접수신공능손상검사적48례환자위연구대상.채용ELISA검측혈청ICAM-1화IL-6농도,채용반자동생화분석의검측혈청기항농도병계산신소구려과솔(eGFR)치.비교eGFR≥90조화eGFR<90조혈청ICAM-1화IL-6농도,병분석혈청ICAM-1화IL-6농도여eGFR적상관성.결과:eGFR<90조(신공능손상조)혈청ICAM-1화IL-6농도균현저고우eGFR≥90조(신공능정상조)(P<0.05).혈청ICAM-1화IL-6농도여eGFR정현저지부상관성(r=-0.9283, P=0.013;r=-0.9369,P=0.001).결론:혈청ICAM-1화IL-6가능여신공능손상유관,차기농도검측구유평개신공능이상적잠재림상개치.
@@@@Objective:To investigate correlation of serum Intercellular adhesion molecule-1 and Interleukin-6 levels with renal injury, to reveal the clinical value of serum ICAM-1 and IL -6 concentration detection for evaluation of renal function injury.Method:48 subjects were collected, who received renal function injury evaluation from August 2011 to July 2012. ELISA was performed to detect serum ICAM-1 and IL -6 concentration,and semi automatic biochemical analyzer was used to measure serum creatinine concentration, which was used for calculation of glomerular filtration rate ( eGFR ) value. Compared serum ICAM-1 and IL -6 concentrations of subjects with eGFR≥ 90 and eGFR < 90 , and analyzed the correlation between serum ICAM-1 and IL -6 concentrations and eGFR value.Result:Serum ICAM-1 and interleukin -6 concentrations of eGFR < 90 group ( renal injury group ) were significantly higher than those of eGFR ≥ 90 group (normal renal function group ) (P<0.05).Serum ICAM-1 and IL -6 concentration and eGFR value of patients with eGFR < 90 were significantly negative correlation (r=-0.9283, P=-0.013; r=-0.9369,P=0.001).Conclusion:The serum ICAM-1 and interleukin -6 levels may correlate with the renal function injury development, and its concentration detection may have potential value for evaluating the degree of renal function injury.