CAJ | 학술논문

溶酶体的完整性对维持细胞正常的代谢非常重要.溶酶体降解含铁的物质会使其内存在大量低质量铁.这些铁主要以还原型Fe(Ⅱ)形式存在并能诱导芬顿反应的发生,导致溶酶体膜完整性破坏.溶酶体膜透性增加会使一系列水解酶和还原铁进入胞浆进而诱导细胞损伤或死亡.此外,自噬在溶酶体铁代谢中也起着至关重要的作用.溶酶体铁处理的异常在一系列肾脏疾病中发挥着重要作用.
용매체적완정성대유지세포정상적대사비상중요.용매체강해함철적물질회사기내존재대량저질량철.저사철주요이환원형Fe(Ⅱ)형식존재병능유도분돈반응적발생,도치용매체막완정성파배.용매체막투성증가회사일계렬수해매화환원철진입포장진이유도세포손상혹사망.차외,자서재용매체철대사중야기착지관중요적작용.용매체철처리적이상재일계렬신장질병중발휘착중요작용.
@@@@The lysosomal compartment is essential for a variety of cellular functions. Degradation of iron-containing macromolecules results in a large amount of low mass iron which exists in redox-active Fe(II) form in lysosomes. Fe(II) is known to catalyze Fenton reactions that may jeopardize lysosomal membrane integrity during oxidative stress. This results in the release of hydrolases and redox-active iron into the cytosol with ensuing damage or cell death. Besides,autophagy act as a crucial role in iron metabolism. Adversely affecting lysosomal iron handling can contribute to a variety of kidney diseases.