CAJ | 학술논문

慢性心力衰竭时,心肌细胞离子流发生异常,细胞稳态调节作用激活,调节离子通道表达谱及其产物,引起多个离子通道电流的改变,从而恢复细胞内外离子流到理想水平,以维持心肌细胞的电稳定和平衡.稳态调节作用有利于心肌细胞的电稳定,大大提高了心肌细胞对环境的适应能力.但由于心肌细胞间稳态调节的不一致性,引起心肌电活动异常,从而导致心律失常的发生.因此在治疗慢性心力衰竭所致的心律失常时,应在减小心肌细胞工作负荷的同时尽可能地逆转离子通道谱的重构,以减少恶性心律失常的发生.本文主要对慢性心力衰竭的稳态调节作用、离子通道谱重构及导致心律失常的机制进行阐述,并简要介绍心律失常的治疗与展望.
만성심력쇠갈시,심기세포리자류발생이상,세포은태조절작용격활,조절리자통도표체보급기산물,인기다개리자통도전류적개변,종이회복세포내외리자류도이상수평,이유지심기세포적전은정화평형.은태조절작용유리우심기세포적전은정,대대제고료심기세포대배경적괄응능력.단유우심기세포간은태조절적불일치성,인기심기전활동이상,종이도치심률실상적발생.인차재치료만성심력쇠갈소치적심률실상시,응재감소심기세포공작부하적동시진가능지역전리자통도보적중구,이감소악성심률실상적발생.본문주요대만성심력쇠갈적은태조절작용、리자통도보중구급도치심률실상적궤제진행천술,병간요개소심률실상적치료여전망.
@@@@When chronic heart failure happened, myocytes regulated ion channel expression spectrum and their products in homostasis to adjust environmental changes. Its purpose is to reduce the myocytes’ load, which greatly improved the myocytes’ adaptability to environment. However, the myocytes electrophysiology change will cause abnormal cardiac electrical activity, resulting in the occurrence of arrhythmia. In this paper, we will talk about the homostasis regulation of ion channel in CHF, the mechanism of arrhythmia, and the therapy of arrhymia.