CAJ | 학술논문

目的研究AP-2γ表达与胃癌发生、分化程度、肿瘤大小、淋巴结转移、临床分期的关系.方法将81例胃癌、胃黏膜癌前病变26例及正常胃黏膜组织34制成组织芯片,采用免疫组化技术检测胃癌、癌前病变及正常组织中AP-2γ表达.结果 AP-2γ表达在胃癌76.54%与癌前病变69.23%明显高于正常胃黏膜35.29%(P<0.05).癌前病变低于胃癌(P<0.05).高分化腺癌AP-2γ表达率40.00%明显低于中分化70.59%与低分化腺癌81.36%(P<0.05).而低分化腺癌显著高于中分化腺癌(P<0.05).≤3.0cm表达59.38%低于>3.0cm的87.76%(P<0.05).淋巴结转移83.64%明显高于无转移61.54%(P<0.05).Ⅰ+Ⅱ期表达59.38%明显低于Ⅲ+Ⅳ期87.76%(P<0.05).结论 AP-2γ在胃癌高表达与胃癌的发生、肿瘤大小、分化程度、淋巴结转移、临床分期密切相关,其可能是胃癌侵袭转移的重要标记.
목적연구AP-2γ표체여위암발생、분화정도、종류대소、림파결전이、림상분기적관계.방법장81례위암、위점막암전병변26례급정상위점막조직34제성조직심편,채용면역조화기술검측위암、암전병변급정상조직중AP-2γ표체.결과 AP-2γ표체재위암76.54%여암전병변69.23%명현고우정상위점막35.29%(P<0.05).암전병변저우위암(P<0.05).고분화선암AP-2γ표체솔40.00%명현저우중분화70.59%여저분화선암81.36%(P<0.05).이저분화선암현저고우중분화선암(P<0.05).≤3.0cm표체59.38%저우>3.0cm적87.76%(P<0.05).림파결전이83.64%명현고우무전이61.54%(P<0.05).Ⅰ+Ⅱ기표체59.38%명현저우Ⅲ+Ⅳ기87.76%(P<0.05).결론 AP-2γ재위암고표체여위암적발생、종류대소、분화정도、림파결전이、림상분기밀절상관,기가능시위암침습전이적중요표기.
@@@@Objective?To investigate the clinicopathologic significance of AP-2γexpression in human gastric cancer. Methods The expression of AP-2γin gastric cancer, precancerosis and normal tissue was examined by immunohistochemistry. Results The level of expression of AP-2γin gastric cancer was 76.54%. significantly higher than 69.23%in precancerosis and 35.29%in normal tissue (P<0.05). AP-2γexpression in well-differentiated was 40%lower than 70.21%in moderately differentiated and 96.67%in poorly differentiated adenocarcinoma, and in moderately differentiated was lower than in poorly differentiated adenocarcinoma, respectively (P<0.05). The expression of AP-2γwas 59.38%in volume≤3.0cm lower than in>3.0cm (P<0.05). The expression of AP-2γof lymph node metastasis was 83.64%(46/55) significantly higher than 61.54%in non-lymph node metastasis (P<0.05). The expression of AP-2γwas 60.98%inⅠ+Ⅱstage, significantly lower than 87.76%in Ⅲ+Ⅳ(P<0.05). Conclusions The expression of AP-2γis closely related to carcinogenesis, tumor size, pathological classification, lymph node metastasis and clinical stage in gastric cancer, it suggest that AP-2γmay be a important biomark of invasion and metastasis.