CAJ | 학술논문

目的采用HPLC法研究了蛇床子素的油/水分配系数.方法通过测定已知logP值的系列化合物和蛇床子素的logK′值,来推算蛇床子素的logP值.结果采用C18,以乙腈-甲醇-磷酸氢二钠(11∶62∶27,0.05mol/L磷酸调pH值3.7)为流动相,检测波长254nm,流速1mL/min测定蛇床子素logP值为3.46.结论采用高效液相色谱法测定蛇床子素logP值具有快速、重现性好、样品不需特殊纯化及能测溶解度较小的化合物.
목적채용HPLC법연구료사상자소적유/수분배계수.방법통과측정이지logP치적계렬화합물화사상자소적logK′치,래추산사상자소적logP치.결과채용C18,이을정-갑순-린산경이납(11∶62∶27,0.05mol/L린산조pH치3.7)위류동상,검측파장254nm,류속1mL/min측정사상자소logP치위3.46.결론채용고효액상색보법측정사상자소logP치구유쾌속、중현성호、양품불수특수순화급능측용해도교소적화합물.
Objective?To study the HPLC method Osthol oil/water distribution coefficient. Method by measuring the known logP value of a series of compounds and Osthole logK 'values to calculate the logP value of osthol. The results were C18, acetonitrile-methanol-phosphate disodium(11∶62∶27, 0.05 mol/L phosphoric acid pH,3.7) as mobile phase, detection wavelength 254nm,flow rate 1mL/min measured osthole logP value of 3.46. Conclusion Determination of logP values osthole a rapid, reproducible, and the sample can be measured without special purification, and solubility of the smaller compounds.