中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2013年
9期
428-429
,共2页
NF-κB%血管生成%复发%OEC
NF-κB%血管生成%複髮%OEC
NF-κB%혈관생성%복발%OEC
NF-κB%Angiogenesis%Relapse%OEC
目的?研究核因子kappa?B(nuclear?factor-kappa?B,NF-κB)与卵巢上皮癌(ovarian?epithelial?carcinoma,OEC)血管生成及复发的关系.方法?应用免疫组化方法检测36例OEC,15例卵巢良性肿瘤和15例正常卵巢组织微血管密度(Microvessel?density,MVD)?,碱性成纤维生长因子(basic?fibroblast?growth?factor,bFGF?)和NF-κB的表达.同时研究NF-κB?和?bFGF,?MVD关系及OEC患者1、3、5年复发率.结果?NF-κB在OEC中的阳性表达率显著高于良性肿瘤和正常卵巢组织.在NF-κB阳性表达组,MVD和1、3、5年复发率显著高于NF-κB阴性组.NF-κB表达与MVD和bFGF表达正相关.结论?NF-κB可能通过上调bFGF的表达促进血管生成引起OEC的转移和复发.
目的?研究覈因子kappa?B(nuclear?factor-kappa?B,NF-κB)與卵巢上皮癌(ovarian?epithelial?carcinoma,OEC)血管生成及複髮的關繫.方法?應用免疫組化方法檢測36例OEC,15例卵巢良性腫瘤和15例正常卵巢組織微血管密度(Microvessel?density,MVD)?,堿性成纖維生長因子(basic?fibroblast?growth?factor,bFGF?)和NF-κB的錶達.同時研究NF-κB?和?bFGF,?MVD關繫及OEC患者1、3、5年複髮率.結果?NF-κB在OEC中的暘性錶達率顯著高于良性腫瘤和正常卵巢組織.在NF-κB暘性錶達組,MVD和1、3、5年複髮率顯著高于NF-κB陰性組.NF-κB錶達與MVD和bFGF錶達正相關.結論?NF-κB可能通過上調bFGF的錶達促進血管生成引起OEC的轉移和複髮.
목적?연구핵인자kappa?B(nuclear?factor-kappa?B,NF-κB)여란소상피암(ovarian?epithelial?carcinoma,OEC)혈관생성급복발적관계.방법?응용면역조화방법검측36례OEC,15례란소량성종류화15례정상란소조직미혈관밀도(Microvessel?density,MVD)?,감성성섬유생장인자(basic?fibroblast?growth?factor,bFGF?)화NF-κB적표체.동시연구NF-κB?화?bFGF,?MVD관계급OEC환자1、3、5년복발솔.결과?NF-κB재OEC중적양성표체솔현저고우량성종류화정상란소조직.재NF-κB양성표체조,MVD화1、3、5년복발솔현저고우NF-κB음성조.NF-κB표체여MVD화bFGF표체정상관.결론?NF-κB가능통과상조bFGF적표체촉진혈관생성인기OEC적전이화복발.
Objective To investigate the relationship with angiogenesis and relapse of nuclear factor-kappa B(NF-κB)in ovarian epithelial carcinoma (OEC). Methods Microvessel density (MVD), expression of basic fibroblast growth factor (bFGF ) and NF-κB were investigated in 36 cases of OEC, 15 cases of ovarian benign tumor and 15 cases of normal ovarian specimens by immunohistochemical staining. The relationship between the NF-κB and bFGF, MVD and relapse?rate?of?I?,?3?and?5?years?of?OEC?patients?were?also?studied.?Results Positive expression rate of NF-κB in OEC was significantly higher than that of benign tumor and normal ovarian tissue. In NF-κB positive expression group, MVD and relapse rate of 1, 3 and 5 years were significantly higher than those in NF-κB negative group. There were positive relationship between the expression of NF-κB and MVD. Conclusion NF-κB might promote angiogenesis through?up-regulating?bFGF?expression?and?cause?cancer?metastasis?and?relapse?in?OEC.
