CAJ | 학술논문

青蒿素及其衍生物目前已成为抗疟的一线药物,近年来,很多研究已经证实青蒿素及其衍生物具有明显的抗肿瘤作用.其细胞毒性效应主要与活性氧(ROS)的产生有关.其可能作用靶点包括血红素、线粒体及某些特定的蛋白等.其抗肿瘤作用包括抑制肿瘤细胞增殖、抑制肿瘤新生血管生成、抗肿瘤细胞侵袭和转移,以及促进肿瘤细胞凋亡等.青蒿素类药物广谱、高效、低毒,能选择性杀伤肿瘤细胞,逆转肿瘤的多重耐药现象,与多种化疗药物具有协同、增效作用,有望被开发成为新型抗肿瘤药.
청호소급기연생물목전이성위항학적일선약물,근년래,흔다연구이경증실청호소급기연생물구유명현적항종류작용.기세포독성효응주요여활성양(ROS)적산생유관.기가능작용파점포괄혈홍소、선립체급모사특정적단백등.기항종류작용포괄억제종류세포증식、억제종류신생혈관생성、항종류세포침습화전이,이급촉진종류세포조망등.청호소류약물엄보、고효、저독,능선택성살상종류세포,역전종류적다중내약현상,여다충화료약물구유협동、증효작용,유망피개발성위신형항종류약.
The artemisinin and its derivatives are the frontline drugs for the treatment of malaria at present, which has been proved to have significant anti-tumor effects in recent years. Its cytotoxic effect is primarily concerned with the generation of active oxygen species (ROS). The possible targets including heme, mitochondrial and certain proteins. Its anti-tumor effects including inhibition of proliferation , angiogenesis, invasion and metastasis of tumor cells, induction of apoptosis. In summary, the artemisinin compounds,which with broad-spectrum, high efficiency,and low toxicity, can selectively kill cancer cells, retroconverse themultidrug resistance for cancer cells,and also have chemosensitizing/synergistic effects with many chemotherapy drugs.Therefor,they are expected to be developed as new anticancer drugs.