CAJ | 학술논문

目的探讨细胞质胸苷激酶(TK 1)在乳腺癌组织中的表达情况,并分析其与Ki-67及临床病理因素间的关系.方法应用免疫组化Max Vison法检测70例乳腺癌组织标本中TK 1及Ki-67的表达情况,分析二者与乳腺癌各临床病理学参数间的关系.结果 TK 1和Ki-67在70例乳腺癌中的表达与患者年龄、组织学分级、淋巴结转移情况及临床分期相关(分别为χ2=13.40,χ2=12.02,χ2=5.71,χ2=20.26,P<0.05),但与肿瘤大小无关,且TK 1与Ki-67间呈正相关(r=0.888,P<0.01).结论 TK 1表达在不同级别乳腺癌组织中存在差异,分级高者表达高;TK 1同Ki 67一样是一个灵敏的反应肿瘤细胞增殖的指标.
목적탐토세포질흉감격매(TK 1)재유선암조직중적표체정황,병분석기여Ki-67급림상병리인소간적관계.방법응용면역조화Max Vison법검측70례유선암조직표본중TK 1급Ki-67적표체정황,분석이자여유선암각림상병이학삼수간적관계.결과 TK 1화Ki-67재70례유선암중적표체여환자년령、조직학분급、림파결전이정황급림상분기상관(분별위χ2=13.40,χ2=12.02,χ2=5.71,χ2=20.26,P<0.05),단여종류대소무관,차TK 1여Ki-67간정정상관(r=0.888,P<0.01).결론 TK 1표체재불동급별유선암조직중존재차이,분급고자표체고;TK 1동Ki 67일양시일개령민적반응종류세포증식적지표.
Objective To investigate the expression of TK 1 and its correlation of TK 1 with Ki-67 and conventional pathological parameters in breast cancer. Methods TK 1 and Ki-67 expressions in 70 cases of breast cancer were detected by immunohistochemical method. The relationship between expression status of two makers and breast cancer′s clinic pathological parameters were evaluated. Results Both TK 1 and Ki-67 expression was positively correlated with age, grade, lymph node metastasis and TNM stage, but not with tumor size. There was a significant correlation between the expression of TK 1 and Ki-67 (r=0.888, P<0.01).Conclusion The higher histological grade and TNM stage of tumor are, the higher expressions of TK 1 and Ki-67 are.TK 1 is a sensitive indicator measuring the proliferation of tumor cells.