CAJ | 학술논문

目的对发生药源性肝损害的患者进行调查分析,找出主要致肝损害的药物,分析其临床特点以及病情转归等情况.方法2009年7月-2011年7月收治的确诊为药源性肝损害137例患者作为临床观察对象,回顾分析患者临床资料.结果137例患者中,男性54例(39.41%),女性83例(60.58%)比例约为2:3;年龄15~76岁,平均(43.9±9.8)岁,其中超过50岁患者有59例(43.07%);主要的临床表现为恶心呕吐、全身乏力、厌食等,典型体征为皮肤出现黄疸;治疗后,痊愈76例(55.47%),显效42例(30.66%),无效17例(12.40%),死亡2例(1.46%).结论女性发生药源性肝损害的几率高于男性,而且随着年龄的增长,患病风险增加.病发时及时治疗,可提高治愈率.
목적대발생약원성간손해적환자진행조사분석,조출주요치간손해적약물,분석기림상특점이급병정전귀등정황.방법2009년7월-2011년7월수치적학진위약원성간손해137례환자작위림상관찰대상,회고분석환자림상자료.결과137례환자중,남성54례(39.41%),녀성83례(60.58%)비례약위2:3;년령15~76세,평균(43.9±9.8)세,기중초과50세환자유59례(43.07%);주요적림상표현위악심구토、전신핍력、염식등,전형체정위피부출현황달;치료후,전유76례(55.47%),현효42례(30.66%),무효17례(12.40%),사망2례(1.46%).결론녀성발생약원성간손해적궤솔고우남성,이차수착년령적증장,환병풍험증가.병발시급시치료,가제고치유솔.
Objective Objective to happen drug-induced liver injury patients investigations and analysis, found the main hepatic damage drug types, analysis the clinical features and outcome of illness. Methods From July 2009 to July 2011 were diagnosed as our drug-induced liver damage 137 patients as a clinical observation object, patients were retrospectively analyzed the clinical data. Results The 137 patients, male 54 cases (39.41%), the female 83 cases (60.58%) and ratio is about;Age 15 to 76 years old, average (43.9±9.8 years old, more than fifty years old patient have 59 cases (43.07%);The main clinical symptoms of nausea and vomiting, muscle weakness, anorexia, typical signs for the skin appear icteric;After treatment, recovery of 76 patients (55.47%), powerfully 42 patients (30.66%), invalid 17 cases (12.40%), 2 cases died (1.46%). Conclusion Women in drug-induced liver damage probability is higher than men, and as the growth of the age, increased risk. Disease hair when treated, can improve the cure rate.