CAJ | 학술논문

目的探讨脑心舒胶囊对小鼠眩晕症的影响.方法将50只小鼠随机分为脑心舒胶囊高、中、低剂量组(2.4,1.2,0.6 g/kg),阳性组(盐酸地芬尼多片6 mg/kg),空白对照组;灌胃给药7 d后,通过迷宫和平台试验,评价脑心舒胶囊的抗眩晕作用.结果脑心舒胶囊各剂量组均可显著缩短小鼠迷宫逃避时间和平台成功时间,与空白对照组比较差异均有统计学意义(P<0.01),并可增加小鼠进食量.结论脑心舒胶囊能提高小鼠的抗眩晕能力.
목적탐토뇌심서효낭대소서현훈증적영향.방법장50지소서수궤분위뇌심서효낭고、중、저제량조(2.4,1.2,0.6 g/kg),양성조(염산지분니다편6 mg/kg),공백대조조;관위급약7 d후,통과미궁화평태시험,평개뇌심서효낭적항현훈작용.결과뇌심서효낭각제량조균가현저축단소서미궁도피시간화평태성공시간,여공백대조조비교차이균유통계학의의(P<0.01),병가증가소서진식량.결론뇌심서효낭능제고소서적항현훈능력.
Objective To investigate the anti-vertigo effects of Naoxinshu capsule (NC)in mice. Methods Mice were divided into 5 groups at random,namely NC high,medium and low dose groups (2.4,1.2 and 0.6 g/kg, respectively),Difenidol Hydrochloride group (6 mg/kg)and control group (n = 10). After seven days of oral administration,the maze test and platform-jumping test was carried out,respectively. Results NC groups significantly shortened the escaping time in tests,compared to the control group (P<0.01). Besides,NC administration increased food intake of mice. Conclusion NC shows good anti-vertigo effects in mice.