潍坊医学院学报
濰坊醫學院學報
유방의학원학보
JOURNAL OF WEIFANG MEDICAL COLLEGE
2013年
3期
182-184
,共3页
宿超*%陶蓉%王云甲%李慧%李汉高%郑世良
宿超*%陶蓉%王雲甲%李慧%李漢高%鄭世良
숙초*%도용%왕운갑%리혜%리한고%정세량
噻托溴胺%阻塞性肺疾病,慢性%MMP-9%TIMP-1
噻託溴胺%阻塞性肺疾病,慢性%MMP-9%TIMP-1
새탁추알%조새성폐질병,만성%MMP-9%TIMP-1
Tiotropium%Chronic obstructive pulmonary disease%MMP-9%TIMP-1
目的 探讨吸入噻托溴铵对老年慢性阻塞性肺疾病(COPD)患者血清基质金属蛋白酶(MMP-9)及其抑制剂(TIMP-1)的影响.方法 将119例COPD稳定期患者随机分为噻托溴铵组和对照组.对照组应用舒弗美0.2g,每天2次,噻托溴铵组在此基础上加用噻托溴铵吸入治疗,连用3个月.观察两组患者治疗前后肺功能、6min步行距离、呼吸困难评分、不良反应及血清MMP-9,TIMP-1含量的变化.结果 治疗3个月后,与对照组相比较,噻托溴铵组患者肺功能指标(FEV1/预计值、FEV1/FVC、PEF)明显升高,6min步行距离明显改善,呼吸困难评分显著下降(P<0.01);血清MMP-9,TIMP-1水平显著下降(P<0.01).结论 噻托溴铵治疗慢性阻塞性肺疾病的疗效确切,其作用机制可能与其调节血清MMP-9,TIMP-1的表达有关.
目的 探討吸入噻託溴銨對老年慢性阻塞性肺疾病(COPD)患者血清基質金屬蛋白酶(MMP-9)及其抑製劑(TIMP-1)的影響.方法 將119例COPD穩定期患者隨機分為噻託溴銨組和對照組.對照組應用舒弗美0.2g,每天2次,噻託溴銨組在此基礎上加用噻託溴銨吸入治療,連用3箇月.觀察兩組患者治療前後肺功能、6min步行距離、呼吸睏難評分、不良反應及血清MMP-9,TIMP-1含量的變化.結果 治療3箇月後,與對照組相比較,噻託溴銨組患者肺功能指標(FEV1/預計值、FEV1/FVC、PEF)明顯升高,6min步行距離明顯改善,呼吸睏難評分顯著下降(P<0.01);血清MMP-9,TIMP-1水平顯著下降(P<0.01).結論 噻託溴銨治療慢性阻塞性肺疾病的療效確切,其作用機製可能與其調節血清MMP-9,TIMP-1的錶達有關.
목적 탐토흡입새탁추안대노년만성조새성폐질병(COPD)환자혈청기질금속단백매(MMP-9)급기억제제(TIMP-1)적영향.방법 장119례COPD은정기환자수궤분위새탁추안조화대조조.대조조응용서불미0.2g,매천2차,새탁추안조재차기출상가용새탁추안흡입치료,련용3개월.관찰량조환자치료전후폐공능、6min보행거리、호흡곤난평분、불량반응급혈청MMP-9,TIMP-1함량적변화.결과 치료3개월후,여대조조상비교,새탁추안조환자폐공능지표(FEV1/예계치、FEV1/FVC、PEF)명현승고,6min보행거리명현개선,호흡곤난평분현저하강(P<0.01);혈청MMP-9,TIMP-1수평현저하강(P<0.01).결론 새탁추안치료만성조새성폐질병적료효학절,기작용궤제가능여기조절혈청MMP-9,TIMP-1적표체유관.
@@@@ Objective To investigate tiotropium on the clinical efficacy and effect of MMP-9,TIMP-1 in elderly patients with chronic obstructive pulmonary disease .Methods One hundred and nineteen patients with chronic obstructive pulmonary disease were ran -domly divided into the tiotropium group and the control group .The control group received routine to conventional dose of theophylline ,expec-torant agent treatment,and inhaled salbutamol on demand when exacerbated to improve symptoms .The tiotropium group based on the addition of tiotropium was given inhalation therapy once every three months .All patients received 6 minutes walk test,lung function test and the score of life quality before treatment and after three months of therapy respectively ,and adverse effect was also registered in the procedure .Results There was a significant difference between treatment group and control group in Pulmonary function changes (FEV1%,FEV1/FVC,PEF), 6 minutes walk test and clinical symptom (P<0.01).MMP-9 and TIMP-1 in blood serum and sputum was obviously lower in treatment group than in control group.Conclusion Tiotropium in the treatment of chronic obstructive pulmonary disease curative effect ,their mechanisms may be related to the regulation of plasma MMP-9 and TIMP-1 expression.
