CAJ | 학술논문

目的探讨抑癌基因p16、p21和p27的多态性与上皮性卵巢癌易感性的关联.方法选取2007年3月-2011年4月间120例卵巢癌患者作为考察对象,同时选取120例健康女性人群作为对照组.分别采集外周静脉血5ml,提取基因组DNA,分析每个样本的基因型,并做统计学分析.结果两组的p16基因C540G的C/C、C/G和G/G基因型频率分布无显著性差异(P>0.05);两组的p16基因C580T的C/C、C/G和G/G基因型频率分布无显著性差异(P>0.05);两组p21基因的T/T、T/C和C/C基因型频率分布无显著性差异(P>0.05);两组的p27基因的V/V、V/G和G/G基因型频率分布有显著性差异(P<0.05).结论 p16基因和p21基因型的多态性上皮性卵巢癌的易感性有关;p27基因的V/V纯合型可能会增加卵巢癌的发病风险,值得临床关注.
목적탐토억암기인p16、p21화p27적다태성여상피성란소암역감성적관련.방법선취2007년3월-2011년4월간120례란소암환자작위고찰대상,동시선취120례건강녀성인군작위대조조.분별채집외주정맥혈5ml,제취기인조DNA,분석매개양본적기인형,병주통계학분석.결과량조적p16기인C540G적C/C、C/G화G/G기인형빈솔분포무현저성차이(P>0.05);량조적p16기인C580T적C/C、C/G화G/G기인형빈솔분포무현저성차이(P>0.05);량조p21기인적T/T、T/C화C/C기인형빈솔분포무현저성차이(P>0.05);량조적p27기인적V/V、V/G화G/G기인형빈솔분포유현저성차이(P<0.05).결론 p16기인화p21기인형적다태성상피성란소암적역감성유관;p27기인적V/V순합형가능회증가란소암적발병풍험,치득림상관주.
@@@@Objective To study the association of pl6, p21, p27 polymorphism with susceptibility to ovarian cancer. Methods 120 patients with epithelial ovarian cancer in our hospital during March 2007 to April 2011 were selected to study, and 120 healthy women as a control group. Results There were no significant difference(P>0.05) between the frequency of C/C, C/G and G/G genotype in p16 C540G gene of ovarian cancer patients and the control group; there were no significant difference(P>0.05) between the frequency of C/C, C/G and G/G genotype in p16 C580T gene of ovarian cancer patients and the control group; there were no significant difference(P>0.05) between the frequency of C/C, C/G and G/G genotype in p21 gene of ovarian cancer patients and the control group; there wase a significant difference(P<0.05) between the frequency of V/V, V/G and G/G genotype in p27 gene of ovarian cancer patients and the control group. Conclusion Some association of pl6 and p21polymorphism with susceptibility to ovarian cancer, and we found the V/V homozygous of p27 gene may increase the risk of ovarian cancer. It should be concerned in clinical diagnosis.