中国医疗前沿
中國醫療前沿
중국의료전연
CHINA HEALTHCARE INNOVATION
2013年
9期
101
,共1页
AKA%RF%CCP%类风湿
AKA%RF%CCP%類風濕
AKA%RF%CCP%류풍습
AKA%RF%CCP%Rheumatoid
目的同时检测抗环瓜氨酸肽抗体(CCP-Ab)、抗角蛋白抗体(AKA-Ab)、类风湿因子(RF),进一步证实AKA、RF、CCP在类风湿关节炎(RA)患者中的敏感性、特异性和联合检测的意义,探讨早期诊断价值,为临床应用提供依据.方法采用ELISA检测CCP,免疫间接荧光法检测AKA,散射免疫比浊法检测RF.结果 CCP-Ab、AKA-Ab和RF的敏感性和特异性分别为56.99%,96.34%;43.01%,95.1%;58.06%,56.09%.CCP-Ab与AKA-Ab在不同RF含量的阳性率无明显差异,CCP-Ab与AKA-Ab两种方法的检测结果显著相关.结论在对RA早期诊断时,将两种抗体结合起来更有助于对RA早期患者的诊断.
目的同時檢測抗環瓜氨痠肽抗體(CCP-Ab)、抗角蛋白抗體(AKA-Ab)、類風濕因子(RF),進一步證實AKA、RF、CCP在類風濕關節炎(RA)患者中的敏感性、特異性和聯閤檢測的意義,探討早期診斷價值,為臨床應用提供依據.方法採用ELISA檢測CCP,免疫間接熒光法檢測AKA,散射免疫比濁法檢測RF.結果 CCP-Ab、AKA-Ab和RF的敏感性和特異性分彆為56.99%,96.34%;43.01%,95.1%;58.06%,56.09%.CCP-Ab與AKA-Ab在不同RF含量的暘性率無明顯差異,CCP-Ab與AKA-Ab兩種方法的檢測結果顯著相關.結論在對RA早期診斷時,將兩種抗體結閤起來更有助于對RA早期患者的診斷.
목적동시검측항배과안산태항체(CCP-Ab)、항각단백항체(AKA-Ab)、류풍습인자(RF),진일보증실AKA、RF、CCP재류풍습관절염(RA)환자중적민감성、특이성화연합검측적의의,탐토조기진단개치,위림상응용제공의거.방법채용ELISA검측CCP,면역간접형광법검측AKA,산사면역비탁법검측RF.결과 CCP-Ab、AKA-Ab화RF적민감성화특이성분별위56.99%,96.34%;43.01%,95.1%;58.06%,56.09%.CCP-Ab여AKA-Ab재불동RF함량적양성솔무명현차이,CCP-Ab여AKA-Ab량충방법적검측결과현저상관.결론재대RA조기진단시,장량충항체결합기래경유조우대RA조기환자적진단.
@@@@Objective We simultaneously detected CCP-Ab, AKA-Ab and RF to confirm their sensitivity, specificity and significance in rheumatoid arthritis(RA) patients, to provide clinical application in early diagnosis. Methods We used ELISA to detect CCP-Ab, immune indirect fluorescence assay for detection of AKA-Ab, scattering immunoturbidimetry for detection of RF. Results Sensitivity and specificity of CCP-Ab, AKA-Ab and RF were 56.99%, 96.34%; 43.01%, 95.1%and 58.06%, 56.09%, respectively. Percentage of CCP-Ab and AKA-Ab positive patients in different content of RF positive range was not significantly different. However, results of CCP-Ab and AKA-Ab were highly correlated. Conclusion In the early diagnosis of RA, combination of CCP-Ab and AKA-Ab will be more helpful for clinical patients.
