中国医疗前沿
中國醫療前沿
중국의료전연
CHINA HEALTHCARE INNOVATION
2013年
9期
104-105
,共2页
冯志刚%徐名烤%修宁宁%欧日花%李忠信
馮誌剛%徐名烤%脩寧寧%歐日花%李忠信
풍지강%서명고%수저저%구일화%리충신
高尔基体蛋白73%甲胎蛋白%原发性肝癌
高爾基體蛋白73%甲胎蛋白%原髮性肝癌
고이기체단백73%갑태단백%원발성간암
Golgi protein 73%Alpha-fetoprotein%Hepatic cellular carcinoma
目的研究高尔基体蛋白73(Golgi protein 73,GP73)、甲胎蛋白(alpha-fetoprotein,AFP)单独及联合使用在原发性肝癌中的诊断意义.方法选择我院2011年4月-2012年10月门诊、住院患者和健康体检人群,分别用酶联免疫吸附法和化学发光免疫分析法检测47例原发性肝癌、45例肝硬化、387例乙肝携带者、528例健康对照组血清GP73与AFP水平,分析两指标各组间差别,绘制其诊断原发性肝癌的ROC曲线.结果原发性肝癌、肝硬化、乙肝携带者、健康对照组GP73分别为174.22±119.22、127.98±39.71、74.51±40.13、47.08±22.75ng/ml,各组间均存在显著差异.原发性肝癌、肝硬化、乙肝携带者、健康对照组AFP中位数分别为27、3.2、2.8、2.6ng/ml,原发性肝癌组高于其他各组,其他各组间无统计学差异.GP73诊断原发性肝癌ROC曲线的曲线下面积、敏感度、特异度、Youden指数分为别0.819、0.574、0.966、0.540;AFP分别为0.825、0.745、0.846、0.591.两者平行联用敏感度、特异度、Youden指数分别为0.851、0.815、0.666;序贯联用以上指数分别为0.362、0.990、0.352.结论 GP73、AFP两者平行联用敏感度0.851,特异度0.815,对诊断HCC有较好的诊断性能.
目的研究高爾基體蛋白73(Golgi protein 73,GP73)、甲胎蛋白(alpha-fetoprotein,AFP)單獨及聯閤使用在原髮性肝癌中的診斷意義.方法選擇我院2011年4月-2012年10月門診、住院患者和健康體檢人群,分彆用酶聯免疫吸附法和化學髮光免疫分析法檢測47例原髮性肝癌、45例肝硬化、387例乙肝攜帶者、528例健康對照組血清GP73與AFP水平,分析兩指標各組間差彆,繪製其診斷原髮性肝癌的ROC麯線.結果原髮性肝癌、肝硬化、乙肝攜帶者、健康對照組GP73分彆為174.22±119.22、127.98±39.71、74.51±40.13、47.08±22.75ng/ml,各組間均存在顯著差異.原髮性肝癌、肝硬化、乙肝攜帶者、健康對照組AFP中位數分彆為27、3.2、2.8、2.6ng/ml,原髮性肝癌組高于其他各組,其他各組間無統計學差異.GP73診斷原髮性肝癌ROC麯線的麯線下麵積、敏感度、特異度、Youden指數分為彆0.819、0.574、0.966、0.540;AFP分彆為0.825、0.745、0.846、0.591.兩者平行聯用敏感度、特異度、Youden指數分彆為0.851、0.815、0.666;序貫聯用以上指數分彆為0.362、0.990、0.352.結論 GP73、AFP兩者平行聯用敏感度0.851,特異度0.815,對診斷HCC有較好的診斷性能.
목적연구고이기체단백73(Golgi protein 73,GP73)、갑태단백(alpha-fetoprotein,AFP)단독급연합사용재원발성간암중적진단의의.방법선택아원2011년4월-2012년10월문진、주원환자화건강체검인군,분별용매련면역흡부법화화학발광면역분석법검측47례원발성간암、45례간경화、387례을간휴대자、528례건강대조조혈청GP73여AFP수평,분석량지표각조간차별,회제기진단원발성간암적ROC곡선.결과원발성간암、간경화、을간휴대자、건강대조조GP73분별위174.22±119.22、127.98±39.71、74.51±40.13、47.08±22.75ng/ml,각조간균존재현저차이.원발성간암、간경화、을간휴대자、건강대조조AFP중위수분별위27、3.2、2.8、2.6ng/ml,원발성간암조고우기타각조,기타각조간무통계학차이.GP73진단원발성간암ROC곡선적곡선하면적、민감도、특이도、Youden지수분위별0.819、0.574、0.966、0.540;AFP분별위0.825、0.745、0.846、0.591.량자평행련용민감도、특이도、Youden지수분별위0.851、0.815、0.666;서관련용이상지수분별위0.362、0.990、0.352.결론 GP73、AFP량자평행련용민감도0.851,특이도0.815,대진단HCC유교호적진단성능.
@@@@Objective To assess diagnostic value of Golgi protein 73(GP73) and alpha-fetoprotein(AFP) in hepatic cellular carcinoma(HCC). Methods Among wards, out-patients and healthy check people in our hospital from April 2011 to October 2012, 47 HCC, 45 hepatic cirrhosis, 387 HBV carriers and 528 healthy control people were involved in the study. GP73 in serum was measured by ELISA and AFP was measured by ADVIA Centaur XP Immunoassay System. The sensitivity, specification were calculated. Results GP73 in HCC, hepatic cirrhosis, HBV carriers and healthy control people were 174.22 ±119.22, 127.98±39.71, 74.51±40.13, 47.08±22.75ng/ml and showed significance difference. The medians of AFP in HCC, hepatic cirrhosis, HBV carriers and healthy control people were 27, 3.2, 2.8 and 2.6ng/ml. AFP in HCC showed significance difference. The summary estimates for serum GP73 in HCC in the study included were as follows: area under curve ROC, 0.819; sensitivity, 0.574; specificity, 0.966 and Youden index 0.540. Those of AFP were 0.825, 0.745, 0.846 and 0.591. Sensitivity, specificity and Youden index for parallel combination of GP73 and AFP in HCC are 0.851, 0.815 and 0.666; those for sequential combination are 0.362, 0.990 and 0.352. Conclusion With sensitivity 0.851 and specificity 0.815 for parallel combination of GP73 and AFP, it has a fine diagnostics performance in HCC.
