中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2013年
10期
4
,共1页
脑膜炎%结核%隐球菌%γ干扰素%诊断
腦膜炎%結覈%隱毬菌%γ榦擾素%診斷
뇌막염%결핵%은구균%γ간우소%진단
Meningitis%Tuberculosis%Neoformans%IFN-γ%Diagnosis
目的探讨外周血结核杆菌抗原特异性γ干扰素水平在结核性脑膜炎与隐球菌性脑膜炎鉴别诊断中的作用.方法回顾性分析本院13例菌阳结核性脑膜炎、15菌阴结核性脑膜炎及11例隐球菌性脑膜炎患者外周血结核杆菌抗原特异性γ干扰素水平差异.结果菌阳结核性脑膜炎患者外周血结核杆菌抗原特异性γ干扰素9例阳性,4例阴性,阳性率69.2%,菌阴结核性脑膜炎患者外周血结核杆菌抗原特异性γ干扰素10例阳性,5例阴性,阳性率66.7%,隐球菌性脑膜炎患者外周血结核杆菌抗原特异性γ干扰素1例阳性,10例阴性,阳性率0.09%,列联表资料的χ2检验(χ2=6.78,P=0.001),三组阳性率有差别,经组间两两比较,菌阳结核性脑膜炎与菌阴结核性脑膜炎阳性率无显著性差异(χ2=4.31,P=0.07),菌阳结核性脑膜炎与隐球菌性脑膜炎阳性率有显著性差异(χ2=7.37,P=0.013),菌阴结核性脑膜炎与隐球菌性脑膜炎阳性率有显著性差异(χ2=8.26,P=0.024).结论外周血结核杆菌抗原特异性γ干扰素检测可作为结核性脑膜炎与隐球菌性脑膜炎早期鉴别诊断的辅助手段.
目的探討外週血結覈桿菌抗原特異性γ榦擾素水平在結覈性腦膜炎與隱毬菌性腦膜炎鑒彆診斷中的作用.方法迴顧性分析本院13例菌暘結覈性腦膜炎、15菌陰結覈性腦膜炎及11例隱毬菌性腦膜炎患者外週血結覈桿菌抗原特異性γ榦擾素水平差異.結果菌暘結覈性腦膜炎患者外週血結覈桿菌抗原特異性γ榦擾素9例暘性,4例陰性,暘性率69.2%,菌陰結覈性腦膜炎患者外週血結覈桿菌抗原特異性γ榦擾素10例暘性,5例陰性,暘性率66.7%,隱毬菌性腦膜炎患者外週血結覈桿菌抗原特異性γ榦擾素1例暘性,10例陰性,暘性率0.09%,列聯錶資料的χ2檢驗(χ2=6.78,P=0.001),三組暘性率有差彆,經組間兩兩比較,菌暘結覈性腦膜炎與菌陰結覈性腦膜炎暘性率無顯著性差異(χ2=4.31,P=0.07),菌暘結覈性腦膜炎與隱毬菌性腦膜炎暘性率有顯著性差異(χ2=7.37,P=0.013),菌陰結覈性腦膜炎與隱毬菌性腦膜炎暘性率有顯著性差異(χ2=8.26,P=0.024).結論外週血結覈桿菌抗原特異性γ榦擾素檢測可作為結覈性腦膜炎與隱毬菌性腦膜炎早期鑒彆診斷的輔助手段.
목적탐토외주혈결핵간균항원특이성γ간우소수평재결핵성뇌막염여은구균성뇌막염감별진단중적작용.방법회고성분석본원13례균양결핵성뇌막염、15균음결핵성뇌막염급11례은구균성뇌막염환자외주혈결핵간균항원특이성γ간우소수평차이.결과균양결핵성뇌막염환자외주혈결핵간균항원특이성γ간우소9례양성,4례음성,양성솔69.2%,균음결핵성뇌막염환자외주혈결핵간균항원특이성γ간우소10례양성,5례음성,양성솔66.7%,은구균성뇌막염환자외주혈결핵간균항원특이성γ간우소1례양성,10례음성,양성솔0.09%,렬련표자료적χ2검험(χ2=6.78,P=0.001),삼조양성솔유차별,경조간량량비교,균양결핵성뇌막염여균음결핵성뇌막염양성솔무현저성차이(χ2=4.31,P=0.07),균양결핵성뇌막염여은구균성뇌막염양성솔유현저성차이(χ2=7.37,P=0.013),균음결핵성뇌막염여은구균성뇌막염양성솔유현저성차이(χ2=8.26,P=0.024).결론외주혈결핵간균항원특이성γ간우소검측가작위결핵성뇌막염여은구균성뇌막염조기감별진단적보조수단.
Objective?To discuss clinical application of Mycobacterium tuberculosis antigen specific IFN-γresponses in antidiastole between tuberculous meningitis and cryptococal neoformans meningitis. Methods IFN-γresponses in peripheral blood of 13 patients with csf positive tuberculous meningitis , 15 patients with csf negative tuberculous meningitis and 11 patients with cryptococal neoformans meningitis were tested and then analyzed retrospectively. Results Positive IFN-γresponses were detected in 69.2%(9/13)of patients with csf positive tuberculous meningitis, 66.7%(10/15)of patients with csf negative tuberculous meningitis and 9.0%(1/11) of patients with cryptococal neoformans meningitis. IFN-γresponses in the three groups is statistically different(χ2=6.78,P=0.001). Through the comparison between the two two groups, IFN-γresponses positive rate between csf positive tuberculous meningitis patients and csf negative tuberculous meningitis patients is not statistically different(χ2=4.31,P=0.07). IFN-γresponses positive rate between csf positive tuberculous meningitis patients and cryptococal neoformans meningitis patients is statistically different(χ2=7.37,P=0.013). IFN-γresponses positive rate between csf negative tuberculous meningitis patients and cryptococal neoformans meningitis patients is statistically different(χ2=8.26,P=0.024).Conclusion IFN-γresponses in peripheral blood can be used as an assistant means to discriminate cryptococal neoformans meningitis from tuberculous meningitis.
