CAJ | 학술논문

目的观察中西医结合治疗儿童咳嗽变异性哮喘(CVA)的疗效.方法将2010年1月至2011年12月我院儿科门诊就诊CVA患儿85例,病例随机分为两组,对照组采用丙酸氟替卡松气雾剂(ICS)吸入,;治疗组在对照组用药的基础上,根据中医辨证分型,分别加服本院自制中药麻杏清肺口服液、芪风健中口服液、芪芍健脾口服液.治疗共8周.研究期间共有6次访视,评估治疗组、对照组经治疗后CVA患儿症状评分、最大呼气峰流(PEF)值变化和1年内复发率.结果对照组患儿症状评分(治疗前4.0~治疗7周0.84),治疗组患儿症状评分(治疗前4.3~治疗7周0.34)两组均有明显下降(P均<0.01);对照组PEF值(治疗前65.06%~治疗7周89.54%),治疗组PEF值(治疗前65.68%~治疗7周96.74%)两组均有明显升高(P均<0.001);两组比较以治疗组为更优(P<0.05).对照组1年内复发率28.57%,治疗组1年内复发率6..98%,两组比较有显著意义(P<0.05).结论 ICS吸入联合中药治疗,能更好地改善CVA患儿的症状评分、提高PEF值、减少复发率,值得临床推广和应用.
목적관찰중서의결합치료인동해수변이성효천(CVA)적료효.방법장2010년1월지2011년12월아원인과문진취진CVA환인85례,병례수궤분위량조,대조조채용병산불체잡송기무제(ICS)흡입,;치료조재대조조용약적기출상,근거중의변증분형,분별가복본원자제중약마행청폐구복액、기풍건중구복액、기작건비구복액.치료공8주.연구기간공유6차방시,평고치료조、대조조경치료후CVA환인증상평분、최대호기봉류(PEF)치변화화1년내복발솔.결과대조조환인증상평분(치료전4.0~치료7주0.84),치료조환인증상평분(치료전4.3~치료7주0.34)량조균유명현하강(P균<0.01);대조조PEF치(치료전65.06%~치료7주89.54%),치료조PEF치(치료전65.68%~치료7주96.74%)량조균유명현승고(P균<0.001);량조비교이치료조위경우(P<0.05).대조조1년내복발솔28.57%,치료조1년내복발솔6..98%,량조비교유현저의의(P<0.05).결론 ICS흡입연합중약치료,능경호지개선CVA환인적증상평분、제고PEF치、감소복발솔,치득림상추엄화응용.
Objective?Observed integrative efficacy of the treatment of children with cough variant asthma (CVA). Method 85 cases who were diagnosed as CVA in Pediatrics of our hospital during 2010.01 to 2011.12 were randomly divided into two groups. Control group cases were treated by fluticasone propionate aerosol (ICS), treatment group cases taked hospital homemade Chinese medicine respectively (Maxing Qingfei oral Liquid, Qifeng Jianzhong Oral Liquid, Qi Shao Jian Pi oral solution), which were based on typing differentiation to traditional Chinese medicine. Course of treatment was 8 weeks. Symptom scores, peak expiratory flow (PEF) values change and 1-year recurrence rate were assessed in two groups during 6 follow-up. Result Score on symptoms were significantly reduced in both groups (P<0.01).Peak expiratory flow (PEF) were significantly increased in both groups. 1-year recurrence rate of control group was 28.57%, and was 6..98%in treatment group. The Difference was significantly between control group and treatment group(P<0.05). Conclusion The treatment combined ICS inhalation and Chinese medicine can improve the Symptom scores, increase .Peak expiratory flow and reduce 1-year recurrence rate, so this therapy worthy of clinical application.