中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2013年
10期
40-41
,共2页
冠心病%急性冠脉综合征%超敏C反应蛋白%同型半胱氨酸%白细胞介素-10
冠心病%急性冠脈綜閤徵%超敏C反應蛋白%同型半胱氨痠%白細胞介素-10
관심병%급성관맥종합정%초민C반응단백%동형반광안산%백세포개소-10
Coronary heart disease%Acute coronary syndrome%High sensitive c-reactive protein%Homocysteine%Interleukin-10
目的探讨超敏C反应蛋白(hs-CRP)、同型半胱氨酸(HCY)和白细胞介素-10(IL-10)在冠心病(CHD)患者中的检测意义.方法选择我院2010年6月至2012年6月经冠脉造影检查确诊的CHD患者80例,作为观察组.其中,急性冠脉综合征(ACS)患者42例,稳定性心绞痛(SAP)患者38例.同时选择同期健康体检者40例,作为对照组.检测上述对象血清hs-CRP、HCY和IL-10水平.结果 CHD患者血清hs-CRP和HCY水平较对照组显著增高,差异有统计学意义(均P<0.01);IL-10水平较对照组低,但差异无统计学意义(P>0.05).ACS和SAP患者血清hs-CRP和HCY水平较对照组显著增高,ACS患者血清IL-10水平较对照组显著降低,差异均有统计学意义(P<0.01或P<0.05);SAP患者血清IL-10水平较对照组低,但差异无统计学意义(P>0.05).ACS患者血清hs-CRP和HCY水平较SAP患者显著增高,而IL-10水平则较SAP患者显著降低,差异均有统计学意义(P<0.01或P<0.05).结论血清hs-CRP、HCY和IL-10水平与CHD的发生、发展关系密切,三项指标联合检测,对评估CHD病情,尤其对急性冠脉事件的预防、控制具有重要的的临床价值.
目的探討超敏C反應蛋白(hs-CRP)、同型半胱氨痠(HCY)和白細胞介素-10(IL-10)在冠心病(CHD)患者中的檢測意義.方法選擇我院2010年6月至2012年6月經冠脈造影檢查確診的CHD患者80例,作為觀察組.其中,急性冠脈綜閤徵(ACS)患者42例,穩定性心絞痛(SAP)患者38例.同時選擇同期健康體檢者40例,作為對照組.檢測上述對象血清hs-CRP、HCY和IL-10水平.結果 CHD患者血清hs-CRP和HCY水平較對照組顯著增高,差異有統計學意義(均P<0.01);IL-10水平較對照組低,但差異無統計學意義(P>0.05).ACS和SAP患者血清hs-CRP和HCY水平較對照組顯著增高,ACS患者血清IL-10水平較對照組顯著降低,差異均有統計學意義(P<0.01或P<0.05);SAP患者血清IL-10水平較對照組低,但差異無統計學意義(P>0.05).ACS患者血清hs-CRP和HCY水平較SAP患者顯著增高,而IL-10水平則較SAP患者顯著降低,差異均有統計學意義(P<0.01或P<0.05).結論血清hs-CRP、HCY和IL-10水平與CHD的髮生、髮展關繫密切,三項指標聯閤檢測,對評估CHD病情,尤其對急性冠脈事件的預防、控製具有重要的的臨床價值.
목적탐토초민C반응단백(hs-CRP)、동형반광안산(HCY)화백세포개소-10(IL-10)재관심병(CHD)환자중적검측의의.방법선택아원2010년6월지2012년6월경관맥조영검사학진적CHD환자80례,작위관찰조.기중,급성관맥종합정(ACS)환자42례,은정성심교통(SAP)환자38례.동시선택동기건강체검자40례,작위대조조.검측상술대상혈청hs-CRP、HCY화IL-10수평.결과 CHD환자혈청hs-CRP화HCY수평교대조조현저증고,차이유통계학의의(균P<0.01);IL-10수평교대조조저,단차이무통계학의의(P>0.05).ACS화SAP환자혈청hs-CRP화HCY수평교대조조현저증고,ACS환자혈청IL-10수평교대조조현저강저,차이균유통계학의의(P<0.01혹P<0.05);SAP환자혈청IL-10수평교대조조저,단차이무통계학의의(P>0.05).ACS환자혈청hs-CRP화HCY수평교SAP환자현저증고,이IL-10수평칙교SAP환자현저강저,차이균유통계학의의(P<0.01혹P<0.05).결론혈청hs-CRP、HCY화IL-10수평여CHD적발생、발전관계밀절,삼항지표연합검측,대평고CHD병정,우기대급성관맥사건적예방、공제구유중요적적림상개치.
Objective?To explore the clinical significance of combined detection of serum high sensitive c-reactive protein(hs-CRP), homocysteine(HCY) and interleukin-10(IL-10) in patients with coronary heart disease(CHD).Methods We choosed 80 CHD patients diagnosed by coronary angiography as observation group (42 with acute coronary syndrome and 38 with stable angina) and 40 healthy people as normol control group. All aboved subjects were detected the level of serum hs-CRP、HCY and IL-10. Results The level of serum hs-CRP and HCY in patients with CHD were significantly higher than those of the normol control group (respectively, P<0.01);the level of serum IL-10 were lower,but the difference was not statistically significant (P>0.05). The level of serum hs-CRP and HCY in patients with acute coronary syndrome(ACS) and stable angina pectoris(SAP) were significantly higher than those of the normol control group (P<0.01 or 0.05).The level of serum IL-10 in patients with ACS was significantly lower than that of the control group (P<0.05);the level of serum IL-10 in patients with SAP was lower than that of the control group ,but the difference was not statistically significant (P>0.05). The level of serum hs-CRP and HCY in patients with ACS were significantly increased than those of SAP patients (respectively, P<0.01);the level of serum IL-10 in patients with ACS was significantly decreased than that of SAP patients (P<0.01 or 0.05). Conclusion The serum level of hs-CRP、HCY and IL-10 have close relationship with occurrence and development of CHD. The three combined detection has an important clinical value for assessment of coronary heart disease, especially for prevention and control of acute coronary events.
