CAJ | 학술논문

目的:探讨吡柔比星(THP)对膀胱内扁平恶性病变的诊断和治疗价值.方法:对需要经尿道膀胱肿瘤电切术的37例患者术前行膀胱镜检查,观察并记录膀胱内肿瘤生长情况,灌注吡柔比星(50 mg+5%葡萄糖水50 mL)并保留15 min,第二次膀胱镜检,观察膀胱壁内扁平黄染区域并取活检,未染色区域随机取材活检,最后行膀胱肿瘤电切术,术后随访6个月.结果:36例肿瘤患者中,19例患者发现扁平THP染色区域,总染色率为66.7%(24/36),膀胱肿瘤组织染色率58.3%(21/36).THP染色灵敏度为86.2%(25/29),特异度为94.8%(148/156).6个月复发率为25.0%(4/16).结论:用THP作为染色剂,对膀胱内扁平恶性病变诊断有一定价值,操作简便、安全,此方法指导的膀胱肿瘤电切术能够降低患者复发率.
목적:탐토필유비성(THP)대방광내편평악성병변적진단화치료개치.방법:대수요경뇨도방광종류전절술적37례환자술전행방광경검사,관찰병기록방광내종류생장정황,관주필유비성(50 mg+5%포도당수50 mL)병보류15 min,제이차방광경검,관찰방광벽내편평황염구역병취활검,미염색구역수궤취재활검,최후행방광종류전절술,술후수방6개월.결과:36례종류환자중,19례환자발현편평THP염색구역,총염색솔위66.7%(24/36),방광종류조직염색솔58.3%(21/36).THP염색령민도위86.2%(25/29),특이도위94.8%(148/156).6개월복발솔위25.0%(4/16).결론:용THP작위염색제,대방광내편평악성병변진단유일정개치,조작간편、안전,차방법지도적방광종류전절술능구강저환자복발솔.
Objective:This work aimed to evaluate the diagnostic value and therapeutic effect of pirarubicin (THP) on flat malig-nant lesions in the bladder. Methods:Cystoscopic examination of patients required to undergo trans-urethral resection of bladder tumor (TUR-BT) was conducted, and tumor growth in the bladder was observed. Pirarubicin perfusion (50 mL of 50 mg+5%GS) was per-formed in the bladder and maintained for 15 mins. Afterwards, cystoscopic examination of the patients was conducted again, and flat malignant lesions with a yellow region in the urinary bladder wall was observed. Biopsy was then performed in this region and in a ran-dom non-stained area. TUR-BT therapy was performed in all patients, with a 6-month follow-up period after the operation. Results:Flat malignant lesions in THP-stained areas were found in 19 of the 36 tumor patients. The total staining rate was 66.7%(24/36), and the staining rate of bladder tumor tissue was 58.3%(21/36). The sensitivity and specificity of the TPH staining method were 86.2%(25/29) and 94.8%(148/156), respectively. Conclusion:As a staining method, THP is safe and easy to operate and can diagnose flat malig-nant lesions in the bladder. The method can also reduce the recurrence rate of TUR-BT to a certain extent with the aid of THP.