CAJ | 학술논문

目的探讨原发性食管鳞癌(ESCC)组织中mir-183的表达及其与患者临床病理特征、基因表达及预后之间的关系.方法检测83例ESCC组织及癌旁正常组织中mir-183以及基因的表达状况,并对患者的临床病理特征及预后进行分析.结果83例标本中mir-183表达上调51例(61.4%),mir-183表达的上调与ESCC患者的淋巴结转移、拓扑异构酶Ⅱ(TopoⅡ)表达及不良预后有关(均P<0.05).结论 mir-183的表达上调与ESCC的淋巴结转移及TopoⅡ的表达状况有关,并提示预后不良.
목적탐토원발성식관린암(ESCC)조직중mir-183적표체급기여환자림상병리특정、기인표체급예후지간적관계.방법검측83례ESCC조직급암방정상조직중mir-183이급기인적표체상황,병대환자적림상병리특정급예후진행분석.결과83례표본중mir-183표체상조51례(61.4%),mir-183표체적상조여ESCC환자적림파결전이、탁복이구매Ⅱ(TopoⅡ)표체급불량예후유관(균P<0.05).결론 mir-183적표체상조여ESCC적림파결전이급TopoⅡ적표체상황유관,병제시예후불량.
Objective To investigate the expression of microRNA-183 (mir-183) in esophageal squamous-cell carcino-ma(ESCC)and its correlation with disease prognosis. Methods The expression of mir-183 was detected by real-time RT-PCR and immunohistochemistry in 83 ESCC tissue specimens and corresponding pericancerous tissues. Results Among 83 ESCC samples mir-183 was significantly up-regulated (2~6411-fold) in 51 cases compared to the matching pericancerous tissues. Up-regulation of mir-183 expression was correlated with lymph node metastasis, expression of ToPoⅡ and poor prognosis in ESCC patients (al P<0.05). Conclusion Up-regulation of mir-183 expression may indicate the poor prognosis of patients with esophageal squamous cel carcinoma.