CAJ | 학술논문

[目的]评价米氮平对急性白血病(Acute leukemia,AL)化疗患者焦虑、抑郁的疗效及化疗副反应的影响.[方法]70例AL化疗患者根据汉米尔顿焦虑-抑郁量表(HAMA-HAMD)筛选出50例焦虑症(anxiety disorders,AD)和(或)抑郁症(clinical depression,CD)患者,随机法分为治疗组(米氮平组)和对照组,观察4周后评定临床疗效及对化疗不良反应的影响.[结果]AL患者AD和CD的发病呈正相关(P<0.05),并且与患者家庭经济能力及付费方式有关(P<0.01).治疗组HAMA、HAMD评分在化疗后第4周低于化疗前水平(P<0.01),且化疗后第2、4周评分均低于同期对照组(P<0.05).治疗组恶心呕吐、失眠等不良反应较对照组轻(P<0.05),且米氮平不加重肝肾功能损害等化疗副反应(P>0.05).[结论]米氮平干预AL化疗患者伴发A D和(或)C D疗效显著,可减轻化疗不良反应,改善患者生活质量.
[목적]평개미담평대급성백혈병(Acute leukemia,AL)화료환자초필、억욱적료효급화료부반응적영향.[방법]70례AL화료환자근거한미이돈초필-억욱량표(HAMA-HAMD)사선출50례초필증(anxiety disorders,AD)화(혹)억욱증(clinical depression,CD)환자,수궤법분위치료조(미담평조)화대조조,관찰4주후평정림상료효급대화료불량반응적영향.[결과]AL환자AD화CD적발병정정상관(P<0.05),병차여환자가정경제능력급부비방식유관(P<0.01).치료조HAMA、HAMD평분재화료후제4주저우화료전수평(P<0.01),차화료후제2、4주평분균저우동기대조조(P<0.05).치료조악심구토、실면등불량반응교대조조경(P<0.05),차미담평불가중간신공능손해등화료부반응(P>0.05).[결론]미담평간예AL화료환자반발A D화(혹)C D료효현저,가감경화료불량반응,개선환자생활질량.
Objective] To investigate the influence of mirtazapine on anxiety and depression and chemotherapy side effects in acute leukemia patients re-ceiving chemotherapy. [Methods]Fifty patients with anxiety and(or) depression selected from seventy acute leukemia patients by the Hamilton Depression Scale(HAMD) and Hamilton Anxiety Scale(HAMA), were randomly divided into mirtazapine group and control group. Then to evaluate the effect of mirtazapine on anxiety and depression and chemotherapy side effects in the 4 weeks. [Results] The incidence of anxiety was positively correlated with de-pression in acute leukemia patients, both of them were related to economic condition and reimbursement rate. The HAMD and HAMA scores of mirtaza-pine group in the 4 weeks were significantly lower than those before chemotherapy, and both the scores of mirtazapine group in the 2 and 4 weeks were lower than those in controls. The level of chemotherapy side effect in mirtazapine group, such as nausea, vomiting and insomnia, decreased obviously. And mirtazapine didn't worsen other side effects, such as liver and kidney dysfunction. [Conclusion]Mirtazapine may lighten the anxiety and depression in acute leukemia patients receiving chemotherapy, reduce the occurrence of chemotherapy side effects, and improve the quality of life.