CAJ | 학술논문

目的:探讨抑制磷脂酰肌醇-3激酶信号通路对骨髓瘤细胞凋亡的作用.方法:选择笔者所在医院收治的多发性骨髓瘤患者30例,随机分为实验组和对照组.结果:LY294002联合地塞米松的的细胞抑制率、细胞凋亡率、Bcl-2、Bim、Caspase-3、Caspase-9的相对水平与单用地塞米松比较差异有统计学意义(P<0.05).结论:抑制磷脂酰肌醇-3激酶信号通路可有效抑制骨髓瘤细胞凋亡.
목적:탐토억제린지선기순-3격매신호통로대골수류세포조망적작용.방법:선택필자소재의원수치적다발성골수류환자30례,수궤분위실험조화대조조.결과:LY294002연합지새미송적적세포억제솔、세포조망솔、Bcl-2、Bim、Caspase-3、Caspase-9적상대수평여단용지새미송비교차이유통계학의의(P<0.05).결론:억제린지선기순-3격매신호통로가유효억제골수류세포조망.
Objective:To explore the effect of inhibition of PI3K signaling pathway on apoptosis of myeloma cells.Methods:30 patients with MM in our hospital were selected,which were randomly divided into experiment group and control group.Results:Cell inhibition rate,apoptosis rate,Bcl-2,Bim, Caspase-3,Caspase-9 in LY294002 combination with DME had significant differences with DME only (P<0.05).Conclusion:Inhibition of PI3K signaling pathway can effectively inhibit apoptosis of myeloma.