CAJ | 학술논문

研究了增塑剂邻苯二甲酸二(2-乙基)己酯(di-(2-ethyl hexyl)phthalate,DEHP)围生期母体暴露对青春期(6周龄)和成年后部(12周龄)子代小鼠行为的影响。母鼠从妊娠第7天至断乳前(产后21 d)灌胃染毒DEHP(10,50和200 mg/(kg·d)),同时设空白对照组及溶媒对照组。出生后第6和第12周时分别检测仔鼠的活动性、焦虑、空间记忆等行为。结果显示：DEHP暴露显著抑制了青春期雌、雄仔鼠的活动性,增加了其焦虑状态,且加剧的焦虑状态可延续到成年后的雌鼠；损伤青春期雄鼠的空间学习记忆能力,但对青春期雌鼠和成年后雌、雄仔鼠的空间记忆能力没有影响。以上结果提示,发育期DEHP暴露性别特异性地影响仔鼠的多种神经行为,青春期的情感和记忆能力更容易受影响。
연구료증소제린분이갑산이(2-을기)기지(di-(2-ethyl hexyl)phthalate,DEHP)위생기모체폭로대청춘기(6주령)화성년후부(12주령)자대소서행위적영향。모서종임신제7천지단유전(산후21 d)관위염독DEHP(10,50화200 mg/(kg·d)),동시설공백대조조급용매대조조。출생후제6화제12주시분별검측자서적활동성、초필、공간기억등행위。결과현시：DEHP폭로현저억제료청춘기자、웅자서적활동성,증가료기초필상태,차가극적초필상태가연속도성년후적자서；손상청춘기웅서적공간학습기억능력,단대청춘기자서화성년후자、웅자서적공간기억능력몰유영향。이상결과제시,발육기DEHP폭로성별특이성지영향자서적다충신경행위,청춘기적정감화기억능력경용역수영향。
The present study investigated the effects of utero and lactational exposure to DEHP (10, 50, and 200 mg/( kg·d) ) from gestation day 7 through postnatal day 21 on the behavior of offspring mice at age of 6 and 12 weeks. The results showed that DEHP exposure significantly inhibited locomotion but increased anxie-ty-like state of pubertal offspring mice of both sexes, and permanently influenced anxiety-like state of females in adulthood. Utero and lactational exposure to DEHP impaired spatial learning and memory function in puber-tal male mice, but not in pubertal females and adult mice of both sexes. These results suggested that develop-mental DEHP exposure sex specifically influenced a variety of neurobehavior, and anxiety and memory of pu-berty were more susceptible to DEHP.