温州医科大学学报
溫州醫科大學學報
온주의과대학학보
Journal of Wenzhou Medical University
2014年
12期
864-867
,共4页
周怀彬%王金丹%胡理怀%温超玮%吕建新
週懷彬%王金丹%鬍理懷%溫超瑋%呂建新
주부빈%왕금단%호리부%온초위%려건신
P450%CYP2C19%CYP2C9%多态性%温州地区%汉族
P450%CYP2C19%CYP2C9%多態性%溫州地區%漢族
P450%CYP2C19%CYP2C9%다태성%온주지구%한족
cytochrome P450%CPY2C19%CYP2C9%polymorphism%Wenzhou%Han population
目的：研究温州地区汉族人群CYP2C19、CYP2C9基因多态性分布。方法：采用聚合酶链式反应和测序方法，对287例健康人群CYP2C19、CYP2C9基因多态性进行分析。结果：温州地区汉族人群的CYP2C19*1、CYP2C19*2和CYP2C19*3三种等位基因的频率分别为65.16%、29.27%和5.57%；CYP2C19*1/*1、CYP2C19*1/*2、CYP2C19*1/*3、CYP2C19*2/*3、CYP2C19*2/*2和CYP2C19*3/*3基因型的频率分别为44.95%、33.45%、6.97%、4.18%、10.45%和0.00%，弱代谢率为14.63%；CYP2C9*1和CYP2C9*3等位基因频率分别为97.74%和2.26%，CYP2C9*1/*1和CYP2C9*1/*3的基因频率为95.47%和4.53%，未发现CYP2C9*3/*3。结论：温州地区汉族人群CYP2C19和CYP2C9弱代谢率与已报道的汉族人群基本一致，与日本人群相近，显著高于欧美人群。
目的：研究溫州地區漢族人群CYP2C19、CYP2C9基因多態性分佈。方法：採用聚閤酶鏈式反應和測序方法，對287例健康人群CYP2C19、CYP2C9基因多態性進行分析。結果：溫州地區漢族人群的CYP2C19*1、CYP2C19*2和CYP2C19*3三種等位基因的頻率分彆為65.16%、29.27%和5.57%；CYP2C19*1/*1、CYP2C19*1/*2、CYP2C19*1/*3、CYP2C19*2/*3、CYP2C19*2/*2和CYP2C19*3/*3基因型的頻率分彆為44.95%、33.45%、6.97%、4.18%、10.45%和0.00%，弱代謝率為14.63%；CYP2C9*1和CYP2C9*3等位基因頻率分彆為97.74%和2.26%，CYP2C9*1/*1和CYP2C9*1/*3的基因頻率為95.47%和4.53%，未髮現CYP2C9*3/*3。結論：溫州地區漢族人群CYP2C19和CYP2C9弱代謝率與已報道的漢族人群基本一緻，與日本人群相近，顯著高于歐美人群。
목적：연구온주지구한족인군CYP2C19、CYP2C9기인다태성분포。방법：채용취합매련식반응화측서방법，대287례건강인군CYP2C19、CYP2C9기인다태성진행분석。결과：온주지구한족인군적CYP2C19*1、CYP2C19*2화CYP2C19*3삼충등위기인적빈솔분별위65.16%、29.27%화5.57%；CYP2C19*1/*1、CYP2C19*1/*2、CYP2C19*1/*3、CYP2C19*2/*3、CYP2C19*2/*2화CYP2C19*3/*3기인형적빈솔분별위44.95%、33.45%、6.97%、4.18%、10.45%화0.00%，약대사솔위14.63%；CYP2C9*1화CYP2C9*3등위기인빈솔분별위97.74%화2.26%，CYP2C9*1/*1화CYP2C9*1/*3적기인빈솔위95.47%화4.53%，미발현CYP2C9*3/*3。결론：온주지구한족인군CYP2C19화CYP2C9약대사솔여이보도적한족인군기본일치，여일본인군상근，현저고우구미인군。
Objective: To investigate distribution status of CYP2C19 and CYP2C9 genotype in Wenzhou Han population.Methods: The CYP2C19 and CYP2C9 genotype of 287 Wenzhou Han Chinese were deter-mined by sequencing.Results: In Wenzhou Han population, CYP2C19*1, CYP2C19*2 and CYP2C19*3 allele frequencies were 65.16%, 29.27% and 13.6%, respectively; CYP2C19*1/*1, CYP2C19*1/*2, CYP2C19*1/*3, CYP2C19*2/*3, CYP2C19*2/*2 and CYP2C19*3/*3 genotype frequencies were 44.95%, 33.45%, 6.97%, 4.18% and 0.00%, respectively. The frequency of CYP2C19 poor metabolisms was 14.63%; CYP2C9*1 and CYP2C9*3 allele frequencies were 97.74% and 2.26%, respectively; CYP2C9*1/*1 and CYP2C9*1/*3 genotype frequencies were 95.47% and 4.53%, respectively, CYP2C9*3/*3 homozygous genotype was not found in this study.Con-clusion: The frequencie of CYP2C19 and CYP2C9 poor metabolisms are similar to those of Japanese population, whereas they are signiifcantly different from America-European populations.
