中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2014年
11期
1184-1187
,共4页
沈继龙%顾红军%裴晓红%周情太%李玲%周雪梅%朱晓轩
瀋繼龍%顧紅軍%裴曉紅%週情太%李玲%週雪梅%硃曉軒
침계룡%고홍군%배효홍%주정태%리령%주설매%주효헌
慢性阻塞性肺疾病%晚期氧化蛋白产物%超氧化物歧化酶%丙二醛
慢性阻塞性肺疾病%晚期氧化蛋白產物%超氧化物歧化酶%丙二醛
만성조새성폐질병%만기양화단백산물%초양화물기화매%병이철
Chronic obstructive pulmonary disease%Advanced oxidation protein products%Superoxide dismutase%Malondialdehyde
目的 检测慢性阻塞性肺疾病(COPD)患者血清晚期氧化蛋白产物(AOPP)的水平,探究AOPP与COPD的相关性及其临床意义.方法 纳入2011年4月至2013年11月来我院就诊的54例轻、中度COPD患者(COPD组);同期收集30名健康志愿者作为健康对照组,两组一般情况相匹配.分别检测血清AOPP、超氧化物歧化酶(SOD)和丙二醛(MDA)的水平.结果 健康对照组血清AOPP为(45.78±12.54) μmol/L、MDA为(2.96±0.55) μmol/L、SOD为(78.40±8.37) kU/L,COPD组血清AOPP为(68.93±10.62) μmol/L、MDA为(6.07±2.44) μmol/L、SOD为(53.66 ±5.99) kU/L,两组比较差异均有统计学意义(t值分别为-8.57、-9.14、14.38,P均＜0.01).轻度COPD组患者血清AOPP为(65.56±9.65) μmol/L、MDA为(4.21±1.83) μmol/L、SOD为(62.97 ±6.28) kU/L,中度COPD组血清AOPP为(71.79±11.37) μmol/L、MDA为(7.43 ±3.12) μmol/L、SOD为(41.25 ±5.89) kU/L,两组比较差异均有统计学意义(t值分别为-2.17、-4.80、13.00,P＜0.05或P＜0.01).结论 血清AOPP水平增高是COPD患者的重要病理变化,可能参与COPD的发生及发展过程,是反映COPD患者氧化应激损伤的早期敏感指标.
目的 檢測慢性阻塞性肺疾病(COPD)患者血清晚期氧化蛋白產物(AOPP)的水平,探究AOPP與COPD的相關性及其臨床意義.方法 納入2011年4月至2013年11月來我院就診的54例輕、中度COPD患者(COPD組);同期收集30名健康誌願者作為健康對照組,兩組一般情況相匹配.分彆檢測血清AOPP、超氧化物歧化酶(SOD)和丙二醛(MDA)的水平.結果 健康對照組血清AOPP為(45.78±12.54) μmol/L、MDA為(2.96±0.55) μmol/L、SOD為(78.40±8.37) kU/L,COPD組血清AOPP為(68.93±10.62) μmol/L、MDA為(6.07±2.44) μmol/L、SOD為(53.66 ±5.99) kU/L,兩組比較差異均有統計學意義(t值分彆為-8.57、-9.14、14.38,P均＜0.01).輕度COPD組患者血清AOPP為(65.56±9.65) μmol/L、MDA為(4.21±1.83) μmol/L、SOD為(62.97 ±6.28) kU/L,中度COPD組血清AOPP為(71.79±11.37) μmol/L、MDA為(7.43 ±3.12) μmol/L、SOD為(41.25 ±5.89) kU/L,兩組比較差異均有統計學意義(t值分彆為-2.17、-4.80、13.00,P＜0.05或P＜0.01).結論 血清AOPP水平增高是COPD患者的重要病理變化,可能參與COPD的髮生及髮展過程,是反映COPD患者氧化應激損傷的早期敏感指標.
목적 검측만성조새성폐질병(COPD)환자혈청만기양화단백산물(AOPP)적수평,탐구AOPP여COPD적상관성급기림상의의.방법 납입2011년4월지2013년11월래아원취진적54례경、중도COPD환자(COPD조);동기수집30명건강지원자작위건강대조조,량조일반정황상필배.분별검측혈청AOPP、초양화물기화매(SOD)화병이철(MDA)적수평.결과 건강대조조혈청AOPP위(45.78±12.54) μmol/L、MDA위(2.96±0.55) μmol/L、SOD위(78.40±8.37) kU/L,COPD조혈청AOPP위(68.93±10.62) μmol/L、MDA위(6.07±2.44) μmol/L、SOD위(53.66 ±5.99) kU/L,량조비교차이균유통계학의의(t치분별위-8.57、-9.14、14.38,P균＜0.01).경도COPD조환자혈청AOPP위(65.56±9.65) μmol/L、MDA위(4.21±1.83) μmol/L、SOD위(62.97 ±6.28) kU/L,중도COPD조혈청AOPP위(71.79±11.37) μmol/L、MDA위(7.43 ±3.12) μmol/L、SOD위(41.25 ±5.89) kU/L,량조비교차이균유통계학의의(t치분별위-2.17、-4.80、13.00,P＜0.05혹P＜0.01).결론 혈청AOPP수평증고시COPD환자적중요병리변화,가능삼여COPD적발생급발전과정,시반영COPD환자양화응격손상적조기민감지표.
Objective To investigate the serum levels of advanced oxidation protein products (AOPP) in patients with chronic obstructive pulmonary disease (COPD) as well as explore the relevance of its clinical significance AOPP and COPD.Methods Fifty-four patients with mild/moderate COPD (COPD group) were enrolled in this study,who were treated in the No.100th Hospital of the Chinese People's Liberation Army from Apr.2011 to Nov.2013.Thirty healthy volunteers (control group) at same period were selected as control group and the general condition of two groups were matched.AOPP,superoxide dismutase(SOD) and malondialdehyde (MDA) levels were measured.Results The serum AOPP,MDA and SOD in control group were (45.78 ± 12.54) μmol/L,(2.96 ± 0.55) μmol/L and (78.40 ± 8.37) kU/L respectively.And its were (68.93 ± 10.62) μmol/L,(6.07 ± 2.44) μmol/L and (53.66 ± 5.99) kU/L respectively in COPD group.The differences were statistically significant (t =-8.57,-9.14,14.38 ; All P values were less than 0.01).The serum AOPP,MDA and SOD in mild COPD group were (65.56 ±9.65) μmol/L,(4.21 ± 1.83) μmol/L and (62.97 ± 6.28) kU/L respectively,and (71.79 ± 11.37) μmol/L,(7.43 ± 3.12) μmol/L and (41.25 ± 5.89) kU/L respectively in moderate CODP group.The differences were statistically significant (t =-2.17,-4.80,13.00; P ＜ 0.05 or P ＜ 0.01).Conclusion The increased levels of serum AOPP is important pathological changes in patients with COPD,which may be involved in the occurrence and development of COPD,and is the reaction of oxidative stress injury in patients with COPD early sensitive indicator.
