CAJ | 학술논문

目的：探讨血清甲胎蛋白（A FP ）、甲胎蛋白异质体3（A FP‐L3）、铁蛋白（FER ）和α‐L‐岩藻糖苷酶（AFU ）的联合检测在原发性肝癌（PHC）中的诊断价值。方法选取鼓楼医院2012年1月至2013年12月住院患者200例，包括良性肝病患者87例和PHC患者113例，并选择同期健康体检者80例为健康对照组，对其 AFP、AFP‐L3水平进行检测，同时检测标本中FER和 AFU 的水平，判断其之间的关系。结果 PHC患者AFP、AFP‐L3、FER和AFU水平明显高于良性肝病组和健康对照组，差异有统计学意义（P＜0．05）。经 ROC曲线分析，AFP 405．4 ng／mL、AFP‐L336．6 ng／mL、FER 321．6 ng／mL和AFU 40．2 U／L联合应用的临界值，敏感度可达84％，特异度可达82％，均高于单项指标诊断。结论联合检测血清AFP、AFP‐L3、FER和AFU 在诊断PHC中有重要价值，可提高临床诊断准确性。
목적：탐토혈청갑태단백（A FP ）、갑태단백이질체3（A FP‐L3）、철단백（FER ）화α‐L‐암조당감매（AFU ）적연합검측재원발성간암（PHC）중적진단개치。방법선취고루의원2012년1월지2013년12월주원환자200례，포괄량성간병환자87례화PHC환자113례，병선택동기건강체검자80례위건강대조조，대기 AFP、AFP‐L3수평진행검측，동시검측표본중FER화 AFU 적수평，판단기지간적관계。결과 PHC환자AFP、AFP‐L3、FER화AFU수평명현고우량성간병조화건강대조조，차이유통계학의의（P＜0．05）。경 ROC곡선분석，AFP 405．4 ng／mL、AFP‐L336．6 ng／mL、FER 321．6 ng／mL화AFU 40．2 U／L연합응용적림계치，민감도가체84％，특이도가체82％，균고우단항지표진단。결론연합검측혈청AFP、AFP‐L3、FER화AFU 재진단PHC중유중요개치，가제고림상진단준학성。
Objective To explore the value of combined detection of α‐fetoprotein (AFP) ,AFP heteroplasmon 3 (AFP‐L3 ) ,ferritin (FER ) and α‐L‐fucosidase (AFU ) in the diagnosis of primary hepatic cancer (PHC ) . Methods During Jan .2012 and Dec .2013 ,the levels of AFP ,AFP‐L3 ,FER and AFU were detected and compared a‐mong 87 cases with benign liver diseases (benign liver diseases group) ,113 cases with PHC ,and 80 healthy subjects (control group) .Then ,the diagnostic performance was analyzed .Results The levels of AFP ,AFP‐L3 ,FER and AFU were significantly increased in patients with PHC ,compared with benign liver diseases group and control group (P<0 .05) .Analysis of receiver operating characteristic (ROC) curve indicated that the diagnostic sensitivity and specific‐ity of combined detection of AFP ,AFP‐L3 ,FER and AFU were 84% and 82% ,which were higher than single detec‐tion of these four parameters ,when taking the cut‐off values of 405 .4 ng/mL ,36 .6 ng/mL ,321 .6 ng/mL and 40 .2 U/L for each marker respectively .Conclusion Combined detection of AFP ,AFP‐L3 ,FER and AFU might be with important value for the diagnosis of PHC .