国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2014年
21期
1636-1641
,共6页
睡眠呼吸暂停综合征%晚期氧化蛋白产物%认知功能障碍%氧化应激
睡眠呼吸暫停綜閤徵%晚期氧化蛋白產物%認知功能障礙%氧化應激
수면호흡잠정종합정%만기양화단백산물%인지공능장애%양화응격
Sleep apnea hypopnea syndrome%Advanced oxidation protein products%Cognitive function damage%Oxidative stress
目的 观察OSAHS患者认知功能及血清晚期氧化蛋白产物(AOPP)水平的变化,并分析其相关性.方法 顺序纳入2013年盐城市第一人民医院呼吸科就诊的67例OSAHS患者(OSAHS组),其中男49例,女18例,年龄21～67岁,平均(44±9)岁;同期收集20名健康志愿者(对照组),其中男14名,女6名,两组体质量指数及一般情况相匹配;分别进行多导睡眠图(PSG)监测,根据睡眠呼吸暂停指数(AHID分为轻中重度;应用Epworth嗜睡评分量表(ESS)、简易智能状态量表(MMSE)及画钟试验评估白天嗜睡程度及认知功能,并检测血清氧化应激指标AOPP、超氧化物歧化酶(SOD)和丙二醛的水平.OSAHS组中15例经持续正压通气(CPAP)治疗(治疗组),观察上述指标治疗前后的变化.结果 与对照组比较,OSAHS组及治疗组的MMSE、画钟试验评分降低.与重度OSAHS组比较,治疗组MMSE、画钟试验评分升高.OSAHS组MMSE评分中注意力及计算力、记忆(尤其是短时记忆)评分明显降低[分别为(4.73±0.81)～(2.69±1.38)和(2.85±0.61)～(1.92±0.62)].与对照组比较,OSAHS组及治疗组的血清AOPP和丙二醛水平升高[分别为(78±20)～(117±20) μmol/L和(2.9±1.0)～(6.1±3.0) μmol/L],而SOD水平降低[(89±8)～(57±9)U/ml].与重度OSAHS组比较,治疗组血清AOPP、丙二醛水平降低,SOD水平升高.所有受试者(指OSAHS组及治疗组,不包括对照组,下同)MMSE、画钟试验评分与PSG相关指标(基础SaO2、最低SaO2、AHI、LA/HT、SLT90％)均分别相关.所有受试者血清AOPP、丙二醛、SOD水平与PSG相关指标(最低SaO2、AHI、LA/HT、SLT90％)均分别相关,且差异有统计学意义.血清AOPP、丙二醛、SOD水平与MMSE、画钟试验评分相关,血清AOPP水平与丙二醛、SOD相关,差异有统计学意义.结论 OSAHS患者认知功能障碍与病情的严重程度有关,且主要表现为短时记忆能力和计算能力等方面受损;AOPP是反映OSAHS患者体内蛋白氧化损伤的早期敏感指标,且与其认知功能障碍密切相关.
目的 觀察OSAHS患者認知功能及血清晚期氧化蛋白產物(AOPP)水平的變化,併分析其相關性.方法 順序納入2013年鹽城市第一人民醫院呼吸科就診的67例OSAHS患者(OSAHS組),其中男49例,女18例,年齡21～67歲,平均(44±9)歲;同期收集20名健康誌願者(對照組),其中男14名,女6名,兩組體質量指數及一般情況相匹配;分彆進行多導睡眠圖(PSG)鑑測,根據睡眠呼吸暫停指數(AHID分為輕中重度;應用Epworth嗜睡評分量錶(ESS)、簡易智能狀態量錶(MMSE)及畫鐘試驗評估白天嗜睡程度及認知功能,併檢測血清氧化應激指標AOPP、超氧化物歧化酶(SOD)和丙二醛的水平.OSAHS組中15例經持續正壓通氣(CPAP)治療(治療組),觀察上述指標治療前後的變化.結果 與對照組比較,OSAHS組及治療組的MMSE、畫鐘試驗評分降低.與重度OSAHS組比較,治療組MMSE、畫鐘試驗評分升高.OSAHS組MMSE評分中註意力及計算力、記憶(尤其是短時記憶)評分明顯降低[分彆為(4.73±0.81)～(2.69±1.38)和(2.85±0.61)～(1.92±0.62)].與對照組比較,OSAHS組及治療組的血清AOPP和丙二醛水平升高[分彆為(78±20)～(117±20) μmol/L和(2.9±1.0)～(6.1±3.0) μmol/L],而SOD水平降低[(89±8)～(57±9)U/ml].與重度OSAHS組比較,治療組血清AOPP、丙二醛水平降低,SOD水平升高.所有受試者(指OSAHS組及治療組,不包括對照組,下同)MMSE、畫鐘試驗評分與PSG相關指標(基礎SaO2、最低SaO2、AHI、LA/HT、SLT90％)均分彆相關.所有受試者血清AOPP、丙二醛、SOD水平與PSG相關指標(最低SaO2、AHI、LA/HT、SLT90％)均分彆相關,且差異有統計學意義.血清AOPP、丙二醛、SOD水平與MMSE、畫鐘試驗評分相關,血清AOPP水平與丙二醛、SOD相關,差異有統計學意義.結論 OSAHS患者認知功能障礙與病情的嚴重程度有關,且主要錶現為短時記憶能力和計算能力等方麵受損;AOPP是反映OSAHS患者體內蛋白氧化損傷的早期敏感指標,且與其認知功能障礙密切相關.
목적 관찰OSAHS환자인지공능급혈청만기양화단백산물(AOPP)수평적변화,병분석기상관성.방법 순서납입2013년염성시제일인민의원호흡과취진적67례OSAHS환자(OSAHS조),기중남49례,녀18례,년령21～67세,평균(44±9)세;동기수집20명건강지원자(대조조),기중남14명,녀6명,량조체질량지수급일반정황상필배;분별진행다도수면도(PSG)감측,근거수면호흡잠정지수(AHID분위경중중도;응용Epworth기수평분량표(ESS)、간역지능상태량표(MMSE)급화종시험평고백천기수정도급인지공능,병검측혈청양화응격지표AOPP、초양화물기화매(SOD)화병이철적수평.OSAHS조중15례경지속정압통기(CPAP)치료(치료조),관찰상술지표치료전후적변화.결과 여대조조비교,OSAHS조급치료조적MMSE、화종시험평분강저.여중도OSAHS조비교,치료조MMSE、화종시험평분승고.OSAHS조MMSE평분중주의력급계산력、기억(우기시단시기억)평분명현강저[분별위(4.73±0.81)～(2.69±1.38)화(2.85±0.61)～(1.92±0.62)].여대조조비교,OSAHS조급치료조적혈청AOPP화병이철수평승고[분별위(78±20)～(117±20) μmol/L화(2.9±1.0)～(6.1±3.0) μmol/L],이SOD수평강저[(89±8)～(57±9)U/ml].여중도OSAHS조비교,치료조혈청AOPP、병이철수평강저,SOD수평승고.소유수시자(지OSAHS조급치료조,불포괄대조조,하동)MMSE、화종시험평분여PSG상관지표(기출SaO2、최저SaO2、AHI、LA/HT、SLT90％)균분별상관.소유수시자혈청AOPP、병이철、SOD수평여PSG상관지표(최저SaO2、AHI、LA/HT、SLT90％)균분별상관,차차이유통계학의의.혈청AOPP、병이철、SOD수평여MMSE、화종시험평분상관,혈청AOPP수평여병이철、SOD상관,차이유통계학의의.결론 OSAHS환자인지공능장애여병정적엄중정도유관,차주요표현위단시기억능력화계산능력등방면수손;AOPP시반영OSAHS환자체내단백양화손상적조기민감지표,차여기인지공능장애밀절상관.
Objective To observe the change of patients with obstructive sleep apnea hypopnea syndrome (OSAHS) whose cognitive function and serum advanced oxidation protein (AOPP) levels,and analyze its correlation.Methods Sixty-seven patients with OSAHS (OSAHS group),of the Department of Respiration of First People's Hospital of Yancheng in 2013 were the sequence included,there were 49 cases of men patients,18 cases of women patients,they were from 21 to 67,average ages were (44 ± 9).At the same period,20 healthy volunteers were selected as (control group),there were 14 men,6 women,A BMI and the general situation of two groups were matched,they were given respectively polysomnography (PSG) monitoring,according to the sleep apnea index (AHI),were divided into mild to moderate and severe.Epworth sleepiness scale (ESS) was applied,Mini Mental State Examination (MMSE) and clock drawing test to evaluated the degree of daytime sleepiness and cognitive function,and detected serum oxidative stress indices AOPP,superoxide dismutase (SOD) and the levels of malondialdehyde.In group OSAHS,15 cases were given continuously positive airway pressure (CPAP) treatment (treatment group).and observed the changes of above indexes before and after treatment.Results Compared with the control group,MMSE and the clock drawing test score of OSAHS group and treatment group were lower.Compared with the severe OSAHS group,MMSE,clock drawing test scores of treatment group increased.MMSE score of OSAHS group whose attention,computing power,memory (especially shortterm memory) was significantly reduced respectively [(4.73±0.81)-(2.69± 1.38) and (2.85±0.61)-(1.92±0.62)].Compared with the control group,serum AOPP and MDA levels of OSAHS group and treatment group increased,were separately [(78± 20)-(117 ± 20) μmol/L and (2.9 ± 1.0)-(6.1 ± 3.0)μmol/L],and reduced levels of SOD [(89± 8)-(57 ± 9) U/ml].Compared with the severe OSAHS group,serum AOPP,malondialdehyde levels decreased,the level of SOD increased.All subjects (OSAHS group and treatment group,did not include a control group,the same below) MMSE,clock drawing test score and PSG related index (SaO2,the lowest SaO2,AHI based,LA/HT,SLT90 ％) were related to,they had statistical significance.The serum levels of AOPP,MDA,SOD level and MMSE,clock drawing test score related,serum levels of AOPP and MDA,SOD correlation,the difference has statistical significance.Conclusions Patients with OSAHS whose cognitive dysfunction is related to the severity of symptoms,and the main performance is for the short term memory capacity and computing ability damage.AOPP is a sensitive index to reflect the early oxidative protein damage in patients with OSAHS,and is closely related to cognitive dysfunction.
