CAJ | 학술논문

目的研究急性脑梗死患者血清白细胞介素6(IL-6)与MRI各项指标动态变化,探讨血清IL-6在急性脑梗死后脑水肿形成中的作用.方法测定128例急性脑梗死患者在发病后1、5、14 d的血清IL-6浓度,另外在相应时间点行MRI扫描,处理合成表观扩散系数(ADC)图,测量脑梗死体积、各序列的信号强度比(SIR)、相对表观弥散系数(rADC).另取同一时期的30名健康体检者作为正常对照组,测定空腹状态下血清IL-6浓度.结果急性脑梗死患者在脑梗死后1d,血清IL-6即较正常对照组明显增高,在5d时达高峰水平,14 d时明显降低,各时间点的血清IL-6均明显高于正常对照组(P均=0.000).血清IL-6与脑梗死体积、T2加权像(T2WI)及液体衰减反转恢复(FLAIR)序列的SIR均呈正相关(r值分别为0.750、0.621、0.691,P均=0.000).血清IL-6与T1加权像(T1WI)的SIR呈负相关(r=-0.404,P=0.000),在梗死后1、5d的血清IL-6与弥散加权成像(DWI)序列的SIR呈正相关(r=0.678,P=0.000),脑梗死后1d的血清IL-6与rADC呈负相关(r=-0.826,P=0.000).结论血清IL-6的增高可能促发了缺血性脑水肿的形成、发展.
목적 연구급성뇌경사환자혈청백세포개소6(IL-6)여MRI각항지표동태변화,탐토혈청IL-6재급성뇌경사후뇌수종형성중적작용.방법 측정128례급성뇌경사환자재발병후1、5、14 d적혈청IL-6농도,령외재상응시간점행MRI소묘,처리합성표관확산계수(ADC)도,측량뇌경사체적、각서렬적신호강도비(SIR)、상대표관미산계수(rADC).령취동일시기적30명건강체검자작위정상대조조,측정공복상태하혈청IL-6농도.결과 급성뇌경사환자재뇌경사후1d,혈청IL-6즉교정상대조조명현증고,재5d시체고봉수평,14 d시명현강저,각시간점적혈청IL-6균명현고우정상대조조(P균=0.000).혈청IL-6여뇌경사체적、T2가권상(T2WI)급액체쇠감반전회복(FLAIR)서렬적SIR균정정상관(r치분별위0.750、0.621、0.691,P균=0.000).혈청IL-6여T1가권상(T1WI)적SIR정부상관(r=-0.404,P=0.000),재경사후1、5d적혈청IL-6여미산가권성상(DWI)서렬적SIR정정상관(r=0.678,P=0.000),뇌경사후1d적혈청IL-6여rADC정부상관(r=-0.826,P=0.000).결론 혈청IL-6적증고가능촉발료결혈성뇌수종적형성、발전.
Objective To investigate the function of serum Interleukin-6 (IL-6) in the formation of cerebral edema after acute cerebral infarction through dynamic changes of serum IL-6 and MRI indicators.Methods One hundred and twenty-eight patients with cerebral edema after acute cerebral infarction and 30 healthy were selected as our subjects.The serum IL-6 were measured in at 1,5 and 14 d after acute cerebral infarction.MRI scans were performed in the corresponding time,and then processed synthesis of apparent diffusion coefficients (ADC) graph.Cerebral infarction volume,signal intensity ratio (SIR) of each sequence and relative apparent diffusion coefficient(rADC) were measured and calculated.Results The serum IL-6 in patients with acute cerebral infarction at 1 d after cerebral infarction was significantly higher than that in normal control group and reached the peak level at 5th D after cerebral infarction,significantly decreased at 14th d.The serum IL-6 of each time point were significantly higher than that of normal control group(P =0.000).There were liner positive correlation between the serum IL-6 and the volume of cerebral infarction and SIR of T2 weighted image and fluid attenuation inversion recovery (r =0.750,0.621,0.691 ; P =0.000).The serum of IL-6 and SIR of T1 weighted image was showed negative correlation (r =-0.404,P =0.000).The serum of IL-6 and SIR of diffusion-weighted imaging sequence at 1,5 d after cerebral infarction showed a positive correlation (r =0.678,P =0.000).There was liner negative correlation between the serum IL-6 and rADC at 1 d after cerebral infarction (r =-0.826,P =0.000).Conclusion The rise of serum IL-6 may promote the formation and development of ischemic cerebral edema.