中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2014年
11期
1211-1214
,共4页
血小板减少症%新生儿
血小闆減少癥%新生兒
혈소판감소증%신생인
Thrombocytopenia%Newborn
目的 探讨新生儿血小板减少症的病因及临床特点.方法 回顾性分析71例血小板减少症新生儿临床资料,对比不同胎龄的血小板减少症发病率,并分析病因及临床情况.结果 71例血小板减少症患儿中足月儿34例,早产儿37例,早产儿发生率较足月儿明显增高[2.71％ (37/1 364)与0.89％ (34/3 808),x2=24.56,P＜0.01].常见病因包括宫内生长迟缓、新生儿重度窒息、严重细菌感染(如败血症或坏死性小肠结肠炎)等.宫内生长迟缓引起血小板减少多见于早发性血小板减少症,与晚发性比较差异有统计学意义(x2 =9.20,P=0.002);而严重细菌感染则多见于晚发性血小板减少症(x2=13.58,P＜0.01).轻度血小板减少症患儿临床出血比例明显低于重度血小板减少症患儿(x2=5.85,P =0.016).结论 新生儿血小板减少症常见的病因为宫内生长迟缓,多引起早发性血小板减少,而严重细菌感染多引起晚发性血小板减少,出血比例高,需早期明确诊断,及时针对治疗.
目的 探討新生兒血小闆減少癥的病因及臨床特點.方法 迴顧性分析71例血小闆減少癥新生兒臨床資料,對比不同胎齡的血小闆減少癥髮病率,併分析病因及臨床情況.結果 71例血小闆減少癥患兒中足月兒34例,早產兒37例,早產兒髮生率較足月兒明顯增高[2.71％ (37/1 364)與0.89％ (34/3 808),x2=24.56,P＜0.01].常見病因包括宮內生長遲緩、新生兒重度窒息、嚴重細菌感染(如敗血癥或壞死性小腸結腸炎)等.宮內生長遲緩引起血小闆減少多見于早髮性血小闆減少癥,與晚髮性比較差異有統計學意義(x2 =9.20,P=0.002);而嚴重細菌感染則多見于晚髮性血小闆減少癥(x2=13.58,P＜0.01).輕度血小闆減少癥患兒臨床齣血比例明顯低于重度血小闆減少癥患兒(x2=5.85,P =0.016).結論 新生兒血小闆減少癥常見的病因為宮內生長遲緩,多引起早髮性血小闆減少,而嚴重細菌感染多引起晚髮性血小闆減少,齣血比例高,需早期明確診斷,及時針對治療.
목적 탐토신생인혈소판감소증적병인급림상특점.방법 회고성분석71례혈소판감소증신생인림상자료,대비불동태령적혈소판감소증발병솔,병분석병인급림상정황.결과 71례혈소판감소증환인중족월인34례,조산인37례,조산인발생솔교족월인명현증고[2.71％ (37/1 364)여0.89％ (34/3 808),x2=24.56,P＜0.01].상견병인포괄궁내생장지완、신생인중도질식、엄중세균감염(여패혈증혹배사성소장결장염)등.궁내생장지완인기혈소판감소다견우조발성혈소판감소증,여만발성비교차이유통계학의의(x2 =9.20,P=0.002);이엄중세균감염칙다견우만발성혈소판감소증(x2=13.58,P＜0.01).경도혈소판감소증환인림상출혈비례명현저우중도혈소판감소증환인(x2=5.85,P =0.016).결론 신생인혈소판감소증상견적병인위궁내생장지완,다인기조발성혈소판감소,이엄중세균감염다인기만발성혈소판감소,출혈비례고,수조기명학진단,급시침대치료.
Objective To investigate the cause and clinical characteristics of neonatal thrombocytopenia (NT).Methods A retrospective analysis was performed.71 cases with NT were selected as our subjects.The morbidity of NT was calculated.Results Among the 71 cases with NT,34 were term infants and 37 were preterm infants.The morbidity of NT in preterm infants was significantly higher than that in term infants (x2 =24.56,P ＜0.01).Common causes for NT included intrauterine growth restriction(IUGR),severe asphyxia,severe sepsis or necrotizing enterocolitis (NEC).IUGR was the more frequent cause for early-onset thrombocytopenia than for late-onset thrombocytopenia (x2 =9.20,P =0.002).Severe sepsis or NEC was the more frequent cause for late-onset thrombocytopenia than for early-onset thrombocytopenia (x2 =13.58,P ＜ 0.01).The cases of bleeding in mild thrombocytopenia group was less than that in severe thrombocytopenia group(x2 =5.85,P =0.016).Conclusion IUGR which is the common cause for NT frequently induces earlyonset thrombocytopenia.Severe sepsis or NEC frequently induces late-onset thrombocytopenia accompanied with high bleeding risk.Earlier diagnosis of the cause for NT and tailed treatments can achieve better efficacy.
