中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
31期
24-26
,共3页
林涛%张姝兰%李敬涛%段丽钦
林濤%張姝蘭%李敬濤%段麗欽
림도%장주란%리경도%단려흠
高血压%脉压%肾脏损害%尿微量白蛋白
高血壓%脈壓%腎髒損害%尿微量白蛋白
고혈압%맥압%신장손해%뇨미량백단백
Hypertension%Pulse pressure%Renal injury%Urine microalbumin
目的 观察原发性高血压患者脉压对肾损害的影响.方法 229例轻中度原发性高血压患者行24 h动态血压监测,按24 h平均脉压(MPP)分为EH1(24 h MPP≥60 mmHg,1 mmHg=0.133 kPa)组(128例)和EH2(24 h MPP＜ 60 mmHg)组(101例).依据24 h尿微量白蛋白及肾功能生化测定,观察并比较患者脉压对肾功能的影响.结果 EH1组24 h平均收缩压(MSBP)、24 h MPP明显高于EH2组[(156.20±6.11) mmHg比(143.67±5.46) mmHg,(69.09±5.87) mmHg比(51.15±7.15) mmHg],EH2组24 h平均舒张压(MDBP)明显高于EH1组[(92.52±5.93)mmHg比(87.11±5.52) mmHg],差异有统计学意义(P＜0.01).EH1组24 h尿微量白蛋白较EH2组明显增高[(104.80±24.25) mg比(91.29±24.03) mg],差异有统计学意义(P＜0.01).24 h MPP、24 h MSBP与24 h尿微量白蛋白呈正相关(r=0.259,0.201,P＜ 0.01),24 h MDBP与24 h尿微量白蛋白呈负相关(r=-0.180,P＜0.01).结论 原发性高血压患者24 h MPP与高血压性肾损害密切相关.
目的 觀察原髮性高血壓患者脈壓對腎損害的影響.方法 229例輕中度原髮性高血壓患者行24 h動態血壓鑑測,按24 h平均脈壓(MPP)分為EH1(24 h MPP≥60 mmHg,1 mmHg=0.133 kPa)組(128例)和EH2(24 h MPP＜ 60 mmHg)組(101例).依據24 h尿微量白蛋白及腎功能生化測定,觀察併比較患者脈壓對腎功能的影響.結果 EH1組24 h平均收縮壓(MSBP)、24 h MPP明顯高于EH2組[(156.20±6.11) mmHg比(143.67±5.46) mmHg,(69.09±5.87) mmHg比(51.15±7.15) mmHg],EH2組24 h平均舒張壓(MDBP)明顯高于EH1組[(92.52±5.93)mmHg比(87.11±5.52) mmHg],差異有統計學意義(P＜0.01).EH1組24 h尿微量白蛋白較EH2組明顯增高[(104.80±24.25) mg比(91.29±24.03) mg],差異有統計學意義(P＜0.01).24 h MPP、24 h MSBP與24 h尿微量白蛋白呈正相關(r=0.259,0.201,P＜ 0.01),24 h MDBP與24 h尿微量白蛋白呈負相關(r=-0.180,P＜0.01).結論 原髮性高血壓患者24 h MPP與高血壓性腎損害密切相關.
목적 관찰원발성고혈압환자맥압대신손해적영향.방법 229례경중도원발성고혈압환자행24 h동태혈압감측,안24 h평균맥압(MPP)분위EH1(24 h MPP≥60 mmHg,1 mmHg=0.133 kPa)조(128례)화EH2(24 h MPP＜ 60 mmHg)조(101례).의거24 h뇨미량백단백급신공능생화측정,관찰병비교환자맥압대신공능적영향.결과 EH1조24 h평균수축압(MSBP)、24 h MPP명현고우EH2조[(156.20±6.11) mmHg비(143.67±5.46) mmHg,(69.09±5.87) mmHg비(51.15±7.15) mmHg],EH2조24 h평균서장압(MDBP)명현고우EH1조[(92.52±5.93)mmHg비(87.11±5.52) mmHg],차이유통계학의의(P＜0.01).EH1조24 h뇨미량백단백교EH2조명현증고[(104.80±24.25) mg비(91.29±24.03) mg],차이유통계학의의(P＜0.01).24 h MPP、24 h MSBP여24 h뇨미량백단백정정상관(r=0.259,0.201,P＜ 0.01),24 h MDBP여24 h뇨미량백단백정부상관(r=-0.180,P＜0.01).결론 원발성고혈압환자24 h MPP여고혈압성신손해밀절상관.
Objective To observe the influence of pulse pressure on renal injury in patients with essential hypertension (EH).Methods Two hundred and twenty-nine patients with mild-to-moderate EH completed 24 h ambulatory blood pressure monitoring.The patients were divided into 2 groups according to 24 h mean pulse pressure (MPP):EH 1 (24 h MPP ≥ 60 mmHg,1 mmHg =0.133 kPa) group (128 cases) and EH2 (24 h MPP ＜ 60 mmHg) group (101 cases).According to 24 h urine microalbumin and biochemical determination of renal function,the influence of pulse pressure on kidney function was observed and compared.Results The 24 h mean systolic blood pressure (MSBP) and 24 h MPP in EH1 group were significantly higher than those in EH2 group [(156.20 ±6.11) mmHg vs.(143.67 ±5.46) mmHg,(69.09 ±5.87) mmHg vs.(51.15 ±7.15) mmHg] (P ＜0.01),the 24 h mean diastolic blood pressure (MDBP) in EH2 group was significantly higher than that in EH1 group [(92.52 ±5.93) mmHg vs.(87.11 ± 5.52) mmHg](P＜ 0.01).The 24 h urine microalbumin in EH1 group was significantly higher than that in EH2 group [(104.80 ± 24.25) mg vs.(91.29 ± 24.03) mg] (P ＜ 0.01).There was positive correlation between 24 h MPP,24 h MSBP and 24 h urine microalbumin (r =0.259,0.201,P ＜ 0.01),and there was negative correlation between 24 h MDBP and 24 h urine microalbumin (r =-0.180,P＜ 0.01).Conclusion The 24 h MPP is closely related with the renal injury which is caused by high blood pressure in patients with EH.
