中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
31期
30-32
,共3页
董庆泽%金弢%付畅%熊焰
董慶澤%金弢%付暢%熊燄
동경택%금도%부창%웅염
糖尿病%高血压%胱抑素C
糖尿病%高血壓%胱抑素C
당뇨병%고혈압%광억소C
Diabetic mellitus%Hypertension%Cystatin C
目的 通过对2型糖尿病和原发性高血压患者进行血清胱抑素C(CysC)、肌酐及尿微量白蛋白排泄量(UAE)的检测,评估CysC在糖尿病和高血压早期肾损害诊断中的价值.方法 选择2型糖尿病患者66例,其中38例UAE在30 ～ 300 mg/24 h的患者归入早期糖尿病肾病(DN)组,28例UAE＜ 30 mg/24 h的患者归入无肾病的糖尿病(NDN)组;原发性高血压患者52例,其中25例UAE≥30 mg/24 h的患者归人高血压肾损害组,27例UAE＜ 30 mg/24 h的患者归入高血压无肾损害组;60例健康成年人为对照组.所有入选者检测UAE、CysC、肌酐含量.结果 早期DN组CysC显著高于对照组和NDN组[(1.84±0.83) mg/L比(0.41 ±0.62),(0.66 ±0.59) mg/L],差异有统计学意义(P＜ 0.05);而NDN组CysC与对照组比较差异无统计学意义(P＞0.05);三组肌酐和UAE比较差异均无统计学意义(P＞0.05).高血压肾损害组CysC显著高于对照组和高血压无肾损害组[(0.93±1.04) mg/L比(0.41±0.62),(0.69±0.57) mg/L],差异有统计学意义(P＜0.05);而高血压无肾损害组CysC与对照组比较差异无统计学意义(P＞0.05);三组肌酐和UAE比较差异均无统计学意义(P＞0.05).结论 CysC可作为判断早期肾损害的指标,对患者病情进展有很好的了解,及时采取治疗措施,可降低和避免慢性肾衰竭的发生.
目的 通過對2型糖尿病和原髮性高血壓患者進行血清胱抑素C(CysC)、肌酐及尿微量白蛋白排洩量(UAE)的檢測,評估CysC在糖尿病和高血壓早期腎損害診斷中的價值.方法 選擇2型糖尿病患者66例,其中38例UAE在30 ～ 300 mg/24 h的患者歸入早期糖尿病腎病(DN)組,28例UAE＜ 30 mg/24 h的患者歸入無腎病的糖尿病(NDN)組;原髮性高血壓患者52例,其中25例UAE≥30 mg/24 h的患者歸人高血壓腎損害組,27例UAE＜ 30 mg/24 h的患者歸入高血壓無腎損害組;60例健康成年人為對照組.所有入選者檢測UAE、CysC、肌酐含量.結果 早期DN組CysC顯著高于對照組和NDN組[(1.84±0.83) mg/L比(0.41 ±0.62),(0.66 ±0.59) mg/L],差異有統計學意義(P＜ 0.05);而NDN組CysC與對照組比較差異無統計學意義(P＞0.05);三組肌酐和UAE比較差異均無統計學意義(P＞0.05).高血壓腎損害組CysC顯著高于對照組和高血壓無腎損害組[(0.93±1.04) mg/L比(0.41±0.62),(0.69±0.57) mg/L],差異有統計學意義(P＜0.05);而高血壓無腎損害組CysC與對照組比較差異無統計學意義(P＞0.05);三組肌酐和UAE比較差異均無統計學意義(P＞0.05).結論 CysC可作為判斷早期腎損害的指標,對患者病情進展有很好的瞭解,及時採取治療措施,可降低和避免慢性腎衰竭的髮生.
목적 통과대2형당뇨병화원발성고혈압환자진행혈청광억소C(CysC)、기항급뇨미량백단백배설량(UAE)적검측,평고CysC재당뇨병화고혈압조기신손해진단중적개치.방법 선택2형당뇨병환자66례,기중38례UAE재30 ～ 300 mg/24 h적환자귀입조기당뇨병신병(DN)조,28례UAE＜ 30 mg/24 h적환자귀입무신병적당뇨병(NDN)조;원발성고혈압환자52례,기중25례UAE≥30 mg/24 h적환자귀인고혈압신손해조,27례UAE＜ 30 mg/24 h적환자귀입고혈압무신손해조;60례건강성년인위대조조.소유입선자검측UAE、CysC、기항함량.결과 조기DN조CysC현저고우대조조화NDN조[(1.84±0.83) mg/L비(0.41 ±0.62),(0.66 ±0.59) mg/L],차이유통계학의의(P＜ 0.05);이NDN조CysC여대조조비교차이무통계학의의(P＞0.05);삼조기항화UAE비교차이균무통계학의의(P＞0.05).고혈압신손해조CysC현저고우대조조화고혈압무신손해조[(0.93±1.04) mg/L비(0.41±0.62),(0.69±0.57) mg/L],차이유통계학의의(P＜0.05);이고혈압무신손해조CysC여대조조비교차이무통계학의의(P＞0.05);삼조기항화UAE비교차이균무통계학의의(P＞0.05).결론 CysC가작위판단조기신손해적지표,대환자병정진전유흔호적료해,급시채취치료조시,가강저화피면만성신쇠갈적발생.
Objective To evaluate the significance of cystatin C (CysC) in the diagnosis for early kidney injury of diabetes and hypertension by testing serum CysC and serum creatinine concentration and urinary albumin excretion (UAE) in patients with type 2 diabetes and primary hypertension.Methods Sixty-six patients with type 2 diabetes were selected,among whom the total 38 patients whose UAE were 30-300 mg/24 h were classified into early diabetic nephropathy (DN) group,and 28 patients whose UAE were ＜ 30 mg/24 h were classified into non diabetic nephropathy (NDN) group.Fifty-two patients with primary hypertension were selected,among whom the total 25 patients whose UAE were ≥ 30 mg/24 h were classified into hypertension with kidney injury group,and 27 patients whose UAE were ＜ 30 mg/24 h were classified into hypertension without kidney injury group.Sixty health people were selected as control group.The UAE,CysC and creatinine levels were detected.Results The CysC in early DN group was significantly higher than that in control group and NDN group [(1.84 ± 0.83)mg/L vs.(0.41 ± 0.62) and (0.66 ± 0.59) mg/L],and there was statistical difference (P ＜ 0.05).There was no statistical difference in CysC between NDN group and control group (P ＞ 0.05).There were no statistical differences in creatinine and UAE among the DN group,NDN group and control group (P ＞ 0.05).The CysC in hypertension with kidney injury group was significantly higher than that in control group and hypertension without kidney injury group [(0.93 ± 1.04) mg/L vs.(0.41 ± 0.62) and (0.69 ± 0.57) mg/L],and there was statistical difference (P ＜ 0.05).There was no statistical difference in CysC between hypertension without kidney injury group and control group (P ＞ 0.05).There were statistical differences in creatinine and UAE among hypertension with kidney injury group,hypertension without kidney injury group and control group (P ＞ 0.05).Conclusion CysC can be regarded as the value to judge early kidney injury,and it is very important inunderstanding patient's condition,by which appropriate treatment can be carried out to prevent or decrease the occurrence of chronic renal failure.
