中华消化病与影像杂志(电子版)
中華消化病與影像雜誌(電子版)
중화소화병여영상잡지(전자판)
2014年
6期
24-28
,共5页
胡江峰%刘婷婷%王晓菲%朱睴
鬍江峰%劉婷婷%王曉菲%硃睴
호강봉%류정정%왕효비%주곤
微小RNA-192%肝疾病%肝肿瘤
微小RNA-192%肝疾病%肝腫瘤
미소RNA-192%간질병%간종류
MicroRNA-192%Liver disease%Liver neoplasms
作为新近发现的小分子非编码RNA,微小RNA-192(microRNA-192)在多种肿瘤和非肿瘤疾病中表达异常,并且参与调节多种疾病的发生发展。近年来研究表明,microRNA-192与纤维化相关的细胞因子及胶原蛋白有着紧密的联系。此外,在药物性肝损害模型和肝癌患者的外周循环血中,microRNA-192的表达量明显升高。本文就microRNA-192在慢性肝病、肝癌发生发展中的研究进展作一综述。
作為新近髮現的小分子非編碼RNA,微小RNA-192(microRNA-192)在多種腫瘤和非腫瘤疾病中錶達異常,併且參與調節多種疾病的髮生髮展。近年來研究錶明,microRNA-192與纖維化相關的細胞因子及膠原蛋白有著緊密的聯繫。此外,在藥物性肝損害模型和肝癌患者的外週循環血中,microRNA-192的錶達量明顯升高。本文就microRNA-192在慢性肝病、肝癌髮生髮展中的研究進展作一綜述。
작위신근발현적소분자비편마RNA,미소RNA-192(microRNA-192)재다충종류화비종류질병중표체이상,병차삼여조절다충질병적발생발전。근년래연구표명,microRNA-192여섬유화상관적세포인자급효원단백유착긴밀적련계。차외,재약물성간손해모형화간암환자적외주순배혈중,microRNA-192적표체량명현승고。본문취microRNA-192재만성간병、간암발생발전중적연구진전작일종술。
As a newly discovered small non-coding RNA, the microRNA-192 (miR-192 ) abnormally expresses in a variety of tumor diseases and non-tumor diseases,and participates in the genesis and development of diseases.Studies have shown that miR-192 is closely associated with fibrosis related cytokines and collagens.In addition,miR-192 expression significantly increases in the peripheral circulating blood in drug-induced liver injure model and liver cancer.This article mainly summarizes the latest progress of miR-192 in chronic liver disease and liver cancer.