CAJ | 학술논문

目的：观察注射用尤瑞克林治疗急性进展性脑梗死的临床疗效及不良反应。方法急性进展性脑梗死住院患者128例,随机分为对照组和观察组,对照组(64例)应用常规治疗方案,观察组(64例)在常规治疗方案基础上加用注射用尤瑞克林0.15 PNA,1次/d,疗程14 d,观察两组在治疗前及治疗后14 d的神经功能缺损程度(NIHSS)评分、日常生活活动能力(ADL)评分、临床疗效及不良反应发生情况。结果两组患者治疗后14 d NIHSS、ADL评分均较治疗前明显改善(P<0.05)；观察组显著高于对照组(P<0.05)；临床有效率达81.3%,显著高于对照组68.8%(P<0.05),两组均未发现严重不良反应。结论注射用尤瑞克林治疗急性进展性脑梗死有效并且相对安全。
목적：관찰주사용우서극림치료급성진전성뇌경사적림상료효급불량반응。방법급성진전성뇌경사주원환자128례,수궤분위대조조화관찰조,대조조(64례)응용상규치료방안,관찰조(64례)재상규치료방안기출상가용주사용우서극림0.15 PNA,1차/d,료정14 d,관찰량조재치료전급치료후14 d적신경공능결손정도(NIHSS)평분、일상생활활동능력(ADL)평분、림상료효급불량반응발생정황。결과량조환자치료후14 d NIHSS、ADL평분균교치료전명현개선(P<0.05)；관찰조현저고우대조조(P<0.05)；림상유효솔체81.3%,현저고우대조조68.8%(P<0.05),량조균미발현엄중불량반응。결론주사용우서극림치료급성진전성뇌경사유효병차상대안전。
Objective To observe the clinical effect and adverse reactions of urinary kallidinogenase for injection in the treatment of acute progressive cerebral infarction. Methods A total of 128 patients with acute progressive cerebral infarction were randomly divided into control group and observation group. The control group (n=64) received conventional treatment method, while the observation group (n=64) was treated by additional 0.15 PNA urinary kallidinogenase for injection by 1time/d for 14 d. National institutes of health stroke scale (NIHSS), activities of daily living (ADL) score, clinical effects, and adverse reactions were observed in the two groups before and after 14 d of treatment. Results The scores of NIHSS and ADL were all improved after 14 d of treatment in the two groups (P<0.05), and those in the observation group were higher than in the control group (P<0.05). The clinical effective rate of the observation group was 81.3%, which was obviously higher than 68.8%of the control group (P<0.05). No severe adverse reactions were found in the two groups. Conclusion Treatment of acute progressive cerebral infarction by urinary kallidinogenase for injection is effective and relatively safe.