CAJ | 학술논문

采用H6P2W18O62/SiO2为催化剂，以对羟基苯甲醛、乙酰乙酸乙酯、尿素为原料合成5-乙氧羰基-4-(4-羟基苯基)-6-甲基-3，4-二氢嘧啶-2(1H)-酮.探讨H6P2W18O62/SiO2对本反应的催化活性，较系统地研究了反应物物质的量比、催化剂用量、反应时间、反应温度四因素对产物收率的影响.实验表明：H6P2W18O62/SiO2是合成5-乙氧羰基-4-(4-羟基苯基)-6-甲基-3，4-二氢嘧啶-2(1H)-酮的良好催化剂；在n (对羟基苯甲醛)∶n (乙酰乙酸乙酯)∶n (尿素)=1∶1.5∶1.5，催化剂的用量占反应物料总质量的1.5%，反应温度为80℃，反应时间为60 min的最佳条件下，其收率可达94.4%.
채용H6P2W18O62/SiO2위최화제，이대간기분갑철、을선을산을지、뇨소위원료합성5-을양탄기-4-(4-간기분기)-6-갑기-3，4-이경밀정-2(1H)-동.탐토H6P2W18O62/SiO2대본반응적최화활성，교계통지연구료반응물물질적량비、최화제용량、반응시간、반응온도사인소대산물수솔적영향.실험표명：H6P2W18O62/SiO2시합성5-을양탄기-4-(4-간기분기)-6-갑기-3，4-이경밀정-2(1H)-동적량호최화제；재n (대간기분갑철)∶n (을선을산을지)∶n (뇨소)=1∶1.5∶1.5，최화제적용량점반응물료총질량적1.5%，반응온도위80℃，반응시간위60 min적최가조건하，기수솔가체94.4%.
5-Ethoxycarbonyl-4-(4-hydroxyphenyl)-6-methyl-3,4-dihydropyrimidine-2(1H)-ketone was synthesized by using H6P2W18O62/SiO2 as the catalyst and p-hydroxy benzaldehyde,ethyl acetoacetate and urea as raw materials. Catalytic activity of this reaction using H6P2W18O62/SiO2 as the catalyst was explored. The effects of reaction on the yield of the product were investigated and the optimum conditions were determined as follows:fixing p-hydroxy benzaldehyde consumption is 0.04 mol,n(p-hydroxy benzaldehyde):n(ethyl acetoacetate):n(urea)=1∶1.5∶1.5,the mass ratio of the catalyst to total reactant is 1.5%,the reaction temperature is 80℃, and the reaction time is 1.0 h. The yield of the product was up to 94.4%.