湖北大学学报(自然科学版)
湖北大學學報(自然科學版)
호북대학학보(자연과학판)
2015年
1期
1-6,11
,共7页
马承富%靖海瑞%刘慈%李玉广
馬承富%靖海瑞%劉慈%李玉廣
마승부%정해서%류자%리옥엄
羧基%银配合物%晶体结构%脲酶抑制剂
羧基%銀配閤物%晶體結構%脲酶抑製劑
최기%은배합물%정체결구%뇨매억제제
carboxylates%Ag(I) complex%crystal structure%urease inhibitor
合成并表征了4种羧酸银(I)配合物:[Ag2(L1)2(A1)2]2·H2O(1),[Ag2(L2)2(A2)3]·H2O(2),[Ag(A3)2]2(L3)·10H2O(3)和[Ag2(A4)2](L4)·4H2O(4)(HL1=3-吡啶甲酸;HL2=3,5-二硝基苯甲酸;H2L3=对苯二甲酸;H2L4=4,4’-联苯二甲酸;A1=2-氨基吡啶;A2=2-氨基嘧啶;A3=4-氨基吡啶;A4=1,6-己二胺)。测定了这4种羧酸银(I)配合物抑制脲酶(urease)的效果。实验结果表明4种羧酸银(I)配合物均具有抑制脲酶的生物活性,其中配合物3的抑制活性最强。研究发现它们抑制脲酶的能力随着羧酸银(I)配合物分子聚合程度的增大而减弱。
閤成併錶徵瞭4種羧痠銀(I)配閤物:[Ag2(L1)2(A1)2]2·H2O(1),[Ag2(L2)2(A2)3]·H2O(2),[Ag(A3)2]2(L3)·10H2O(3)和[Ag2(A4)2](L4)·4H2O(4)(HL1=3-吡啶甲痠;HL2=3,5-二硝基苯甲痠;H2L3=對苯二甲痠;H2L4=4,4’-聯苯二甲痠;A1=2-氨基吡啶;A2=2-氨基嘧啶;A3=4-氨基吡啶;A4=1,6-己二胺)。測定瞭這4種羧痠銀(I)配閤物抑製脲酶(urease)的效果。實驗結果錶明4種羧痠銀(I)配閤物均具有抑製脲酶的生物活性,其中配閤物3的抑製活性最彊。研究髮現它們抑製脲酶的能力隨著羧痠銀(I)配閤物分子聚閤程度的增大而減弱。
합성병표정료4충최산은(I)배합물:[Ag2(L1)2(A1)2]2·H2O(1),[Ag2(L2)2(A2)3]·H2O(2),[Ag(A3)2]2(L3)·10H2O(3)화[Ag2(A4)2](L4)·4H2O(4)(HL1=3-필정갑산;HL2=3,5-이초기분갑산;H2L3=대분이갑산;H2L4=4,4’-련분이갑산;A1=2-안기필정;A2=2-안기밀정;A3=4-안기필정;A4=1,6-기이알)。측정료저4충최산은(I)배합물억제뇨매(urease)적효과。실험결과표명4충최산은(I)배합물균구유억제뇨매적생물활성,기중배합물3적억제활성최강。연구발현타문억제뇨매적능력수착최산은(I)배합물분자취합정도적증대이감약。
Four new silver(I) complexes with aromatic carboxylates,[Ag2(L1)2(A1)2]2·H2O(1),[Ag2(L2)2(A2)3]· H2O(2),[Ag(A3)2]2(L3)·10H2O(3) and [Ag2(A4)2](L4)·4H2O(4)(HL1=3-pyridinemethanoic acid;HL2=3,5-dinitrobenzoic acid;H2L3=p-phthalic acid;H2L4=4,4’-biphthalic acid;A1=2-aminopyridine;A2=2-aminopyrimidine;A3=4-aminopyridine;A4=1,6-hexyldiamine),have been synthesized and structurally characterized.Inhibition of jack bean urease by these Ag(I) complexes have been investigated.The Ag(I) complexes (1) (4) possess urease inhibitory activities and complex 3 has the best activity to inhibit urease.It was found that the urease inhibition activity of Ag(I) complexes would decrease with their structural polymerization degree increasing.