CAJ | 학술논문

目的评估白芍总苷联合左西替利嗪及他克莫司软膏治疗严重面部糖皮质激素(简称激素)依赖性皮炎的疗效和安全性.方法共入组98例严重面部激素依赖性皮炎患者,其中63例(试验组)口服白芍总苷胶囊联合左西替利嗪并外用他克莫司软膏治疗,35例(对照组)单纯口服左西替利嗪及外用他克莫司软膏治疗.治疗后第2和4周、停药后2周随访观察患者面部症状及体征,并进行评分,计算有效率.结果临床随访过程中脱落8例,其中试验组脱落3例,对照组脱落5例,最后完成治疗患者共90例.治疗2周后试验组和对照组的有效率分别为50.0％(30/60)和16.7％(5/30),两组比较差异有统计学意义(P＜0.05);治疗4周后试验组和对照组的有效率分别为93.3％(56/60)和60.0％ (18/30),两组比较差异有统计学意义(P＜0.05).停药2周后,所有试验组患者症状总积分持续下降,对照组中53.3％(16/30)患者症状总积分持续下降,26.7％(8/30)患者症状总积分不变,20.0％(6/30)患者症状总积分较停药时上升.两组均无严重不良反应.结论白芍总苷胶囊可以提高左西替利嗪及他克莫司软膏治疗面部严重激素依赖性皮炎的疗效.
목적 평고백작총감연합좌서체리진급타극막사연고치료엄중면부당피질격소(간칭격소)의뢰성피염적료효화안전성.방법 공입조98례엄중면부격소의뢰성피염환자,기중63례(시험조)구복백작총감효낭연합좌서체리진병외용타극막사연고치료,35례(대조조)단순구복좌서체리진급외용타극막사연고치료.치료후제2화4주、정약후2주수방관찰환자면부증상급체정,병진행평분,계산유효솔.결과 림상수방과정중탈락8례,기중시험조탈락3례,대조조탈락5례,최후완성치료환자공90례.치료2주후시험조화대조조적유효솔분별위50.0％(30/60)화16.7％(5/30),량조비교차이유통계학의의(P＜0.05);치료4주후시험조화대조조적유효솔분별위93.3％(56/60)화60.0％ (18/30),량조비교차이유통계학의의(P＜0.05).정약2주후,소유시험조환자증상총적분지속하강,대조조중53.3％(16/30)환자증상총적분지속하강,26.7％(8/30)환자증상총적분불변,20.0％(6/30)환자증상총적분교정약시상승.량조균무엄중불량반응.결론 백작총감효낭가이제고좌서체리진급타극막사연고치료면부엄중격소의뢰성피염적료효.
Objective To evaluate the efficacy and safety of total glucosides of paeony combined with levocetirizine and tacrolimus ointment for the treatment of severe facial corticosteroid-dependent dermatitis.Methods Ninety-eight patients with severe facial corticosteroid-dependent dermatitis were enrolled in this study,and assigned into the test group (n =63) and control group (n =35).The test group were treated with oral total glucosides of paeony capsules and levocetirizine as well as topical 0.03％ tacrolimus ointment,and the control group with oral levocetirizine and topical 0.03％ tacrolimus ointment only.The facial symptoms and signs of patients were observed and scored at week 2 and 4 after starting treatment as well as at week 2 after drug withdrawal.The response rate in these patients was calculated.Results Totally,8 patients (3 in the test group and 5 in the control group) were lost to follow up,and the remaining 90 patients completed the treatment finally.The response rate in the test group was significantly higher than that in the control group at week 2 (50.0％ (30/60) vs.16.7％ (5/30),P ＜ 0.05)and 4 (93.3％ (56/60) vs.60.0％ (18/30),P ＜ 0.05) after starting treatment.During the 2 weeks after drug withdrawal,total symptom scores continuously decreased in all the patients in the test group and in 53.3％ (16/30) of the patients in the control group,maintained unchanged in 26.7％ (8/30) and increased in 20.0％ (6/30) of the patients in the control group.No severe adverse reactions were observed in either of the two groups during the study period.Conclusion Total glucosides of paeony capsules can improve the efficacy of levocetirizine and topical tacrolimus ointment for the treatment of severe facial corticosteroid-dependent dermatitis.