中国心血管杂志
中國心血管雜誌
중국심혈관잡지
CHINESE JOURNAL OF CARDIOVASOLOGY
2014年
6期
422-425
,共4页
氯吡格雷%血小板聚集%血小板聚集抑制剂%急性心肌梗死
氯吡格雷%血小闆聚集%血小闆聚集抑製劑%急性心肌梗死
록필격뢰%혈소판취집%혈소판취집억제제%급성심기경사
Clopidogrel%Platelet aggregation%Platelet aggregation inhibitors%Acute myocardial infarction
目的：观察不同氯吡格雷代谢型急性心肌梗死患者使用氯吡格雷后血小板聚集功能的被抑制情况。方法入选2013年3-8月急性心肌梗死患者48例,经过基因检测分为氯吡格雷慢代谢型6例、快代谢型17例和中间代谢型25例。患者均于入病房前服用负荷剂量阿司匹林300 mg和氯吡格雷300 mg,之后阿司匹林100 mg/d和氯吡格雷75 mg/d连续服用,于服药后第6天检测血小板聚集率、血细胞计数、纤维蛋白原含量和肝肾功能。结果所有患者服用氯吡格雷后第6天的血小板聚集率明显下降,二磷酸腺苷、肾上腺素诱导的抑制率分别为74﹪和84﹪。氯吡格雷快代谢型、中间代谢型和慢代谢型3组急性心肌梗死患者的二磷酸腺苷诱导的血小板聚集率分别为22.2﹪±13.4﹪、32.1﹪±20.1﹪和18.6﹪±13.9﹪(P＞0.05),3组血小板抑制率分别为87﹪、78﹪和82﹪。结论本研究中不同氯吡格雷代谢型急性心肌梗死患者的血小板聚集功能的抑制情况无明显差异。
目的：觀察不同氯吡格雷代謝型急性心肌梗死患者使用氯吡格雷後血小闆聚集功能的被抑製情況。方法入選2013年3-8月急性心肌梗死患者48例,經過基因檢測分為氯吡格雷慢代謝型6例、快代謝型17例和中間代謝型25例。患者均于入病房前服用負荷劑量阿司匹林300 mg和氯吡格雷300 mg,之後阿司匹林100 mg/d和氯吡格雷75 mg/d連續服用,于服藥後第6天檢測血小闆聚集率、血細胞計數、纖維蛋白原含量和肝腎功能。結果所有患者服用氯吡格雷後第6天的血小闆聚集率明顯下降,二燐痠腺苷、腎上腺素誘導的抑製率分彆為74﹪和84﹪。氯吡格雷快代謝型、中間代謝型和慢代謝型3組急性心肌梗死患者的二燐痠腺苷誘導的血小闆聚集率分彆為22.2﹪±13.4﹪、32.1﹪±20.1﹪和18.6﹪±13.9﹪(P＞0.05),3組血小闆抑製率分彆為87﹪、78﹪和82﹪。結論本研究中不同氯吡格雷代謝型急性心肌梗死患者的血小闆聚集功能的抑製情況無明顯差異。
목적：관찰불동록필격뢰대사형급성심기경사환자사용록필격뢰후혈소판취집공능적피억제정황。방법입선2013년3-8월급성심기경사환자48례,경과기인검측분위록필격뢰만대사형6례、쾌대사형17례화중간대사형25례。환자균우입병방전복용부하제량아사필림300 mg화록필격뢰300 mg,지후아사필림100 mg/d화록필격뢰75 mg/d련속복용,우복약후제6천검측혈소판취집솔、혈세포계수、섬유단백원함량화간신공능。결과소유환자복용록필격뢰후제6천적혈소판취집솔명현하강,이린산선감、신상선소유도적억제솔분별위74﹪화84﹪。록필격뢰쾌대사형、중간대사형화만대사형3조급성심기경사환자적이린산선감유도적혈소판취집솔분별위22.2﹪±13.4﹪、32.1﹪±20.1﹪화18.6﹪±13.9﹪(P＞0.05),3조혈소판억제솔분별위87﹪、78﹪화82﹪。결론본연구중불동록필격뢰대사형급성심기경사환자적혈소판취집공능적억제정황무명현차이。
Objective To investigate the inhibition of platelet aggregation of clopidogrel in different clopidogrel metabolizer patients with acute myocardial infarction. Methods A total of 48 patients with acute myocardial infarction were enrolled and divided into extensive ( n =17 ) , intermediate ( n =25 ) or poor metabolizer ( n=6 ) , according to the results of clopidogrel genetic testing. All patients accepted loading dose of aspirin 300 mg and clopidogrel 300 mg at admission, and aspirin 100 mg/d and clopidogrel tablets 75 mg/d continuously. Platelet aggregation, platelet count, fibrinogen levels, liver and kidney function were measured at the 6 th day after admission. Results The platelet aggregation rates in all patients were decreased significantly, and ADP, AA-induced platelet inhibition rates were 74﹪ and 84﹪, respectively. The ADP-induced platelet aggregation rates among three groups ( extensive, intermediate and poor metabolizer) were 22. 2﹪ ± 13. 4﹪, 32. 1﹪ ± 20. 1﹪ and 18. 6﹪ ± 13. 9﹪ ( P >0. 05 ) , and platelet inhibition rates of three groups were 87﹪, 78﹪ and 82﹪ ( P >0. 05 ) . Conclusions There is no significant difference of platelet aggregation in different clopidogrel metabolizer patients with acute myocardial infarction (extensive, intermediate and poor metabolizer) at the 6th day after admission.
