中国心血管杂志
中國心血管雜誌
중국심혈관잡지
CHINESE JOURNAL OF CARDIOVASOLOGY
2014年
6期
418-421
,共4页
血管形成术,经腔,经皮冠状动脉%心肌梗死%性别特征%医院死亡率
血管形成術,經腔,經皮冠狀動脈%心肌梗死%性彆特徵%醫院死亡率
혈관형성술,경강,경피관상동맥%심기경사%성별특정%의원사망솔
Angioplasty,transluminal,percutaneous coronary%Myocardial infarction%Gender identity%Hospital mortality
目的：探讨性别差异是否影响接受直接经皮冠状动脉介入治疗( PCI)的急性ST段抬高型心肌梗死( STEMI)患者的预后。方法选择2008年1月至2013年12月因急性STEMI住院并接受急诊直接PCI治疗的患者578例。比较男性和女性在基线特征、冠状动脉造影结果及住院期间死亡率方面的差异。结果578例患者中男性455例(78.7﹪),女性123例(21.3﹪)。女性的平均年龄较男性大[(68±10)岁比(61±12)岁,t=-6.817,P﹤0.01],高血压(75.6﹪比52.3﹪,x2=21.484,P﹤0.01)和糖尿病(43.1﹪比27.7﹪,x2=10.737,P﹤0.01)的患病率均高于男性；而男性的吸烟比例高于女性(63.5﹪比13.0﹪,x2=99.108,P﹤0.01)。两组患者的冠状动脉造影结果差异无统计学意义。女性的住院期间死亡率高于男性(8.9﹪比4.4﹪,x2=3.945,P=0.047),校正年龄、高血压、糖尿病、吸烟史和血小板糖蛋白Ⅱb/Ⅲa 受体拮抗剂的使用后这种性别差异无统计学意义(OR：1.036,95％CI：0.339~3.169,P=0.95)。结论对接受急诊直接PCI治疗的STEMI患者而言,女性的住院期间死亡率高于男性,但这种差异可能是由于本研究样本人群女性年龄偏大、并存疾病更多所致。
目的：探討性彆差異是否影響接受直接經皮冠狀動脈介入治療( PCI)的急性ST段抬高型心肌梗死( STEMI)患者的預後。方法選擇2008年1月至2013年12月因急性STEMI住院併接受急診直接PCI治療的患者578例。比較男性和女性在基線特徵、冠狀動脈造影結果及住院期間死亡率方麵的差異。結果578例患者中男性455例(78.7﹪),女性123例(21.3﹪)。女性的平均年齡較男性大[(68±10)歲比(61±12)歲,t=-6.817,P﹤0.01],高血壓(75.6﹪比52.3﹪,x2=21.484,P﹤0.01)和糖尿病(43.1﹪比27.7﹪,x2=10.737,P﹤0.01)的患病率均高于男性；而男性的吸煙比例高于女性(63.5﹪比13.0﹪,x2=99.108,P﹤0.01)。兩組患者的冠狀動脈造影結果差異無統計學意義。女性的住院期間死亡率高于男性(8.9﹪比4.4﹪,x2=3.945,P=0.047),校正年齡、高血壓、糖尿病、吸煙史和血小闆糖蛋白Ⅱb/Ⅲa 受體拮抗劑的使用後這種性彆差異無統計學意義(OR：1.036,95％CI：0.339~3.169,P=0.95)。結論對接受急診直接PCI治療的STEMI患者而言,女性的住院期間死亡率高于男性,但這種差異可能是由于本研究樣本人群女性年齡偏大、併存疾病更多所緻。
목적：탐토성별차이시부영향접수직접경피관상동맥개입치료( PCI)적급성ST단태고형심기경사( STEMI)환자적예후。방법선택2008년1월지2013년12월인급성STEMI주원병접수급진직접PCI치료적환자578례。비교남성화녀성재기선특정、관상동맥조영결과급주원기간사망솔방면적차이。결과578례환자중남성455례(78.7﹪),녀성123례(21.3﹪)。녀성적평균년령교남성대[(68±10)세비(61±12)세,t=-6.817,P﹤0.01],고혈압(75.6﹪비52.3﹪,x2=21.484,P﹤0.01)화당뇨병(43.1﹪비27.7﹪,x2=10.737,P﹤0.01)적환병솔균고우남성；이남성적흡연비례고우녀성(63.5﹪비13.0﹪,x2=99.108,P﹤0.01)。량조환자적관상동맥조영결과차이무통계학의의。녀성적주원기간사망솔고우남성(8.9﹪비4.4﹪,x2=3.945,P=0.047),교정년령、고혈압、당뇨병、흡연사화혈소판당단백Ⅱb/Ⅲa 수체길항제적사용후저충성별차이무통계학의의(OR：1.036,95％CI：0.339~3.169,P=0.95)。결론대접수급진직접PCI치료적STEMI환자이언,녀성적주원기간사망솔고우남성,단저충차이가능시유우본연구양본인군녀성년령편대、병존질병경다소치。
Objective A higher mortality risk for women with acute ST elevation myocardial infarction ( STEMI) has been a common finding in the past. It is unclear if these differences persist among patients undergoing contemporary primary percutaneous coronary intervention ( PCI ) with focus on early reperfusion in China. Methods We assessed 578 patients with STEMI undergoing acute coronary angiography with the intention of primary PCI between January 2008 and December 2013. Data were examined for gender-specific differences regarding patients' characteristics, angiographic findings, procedural details, and in-hospital mortality after PCI. Results A total of 123 women and 455 men were included in the study. Compared with men, women were older than men [ (68 ± 10) years old vs. (61 ± 12) years old, t= -6. 817, P﹤0. 01], and more frequently had a history of hypertension (75. 6﹪ vs. 52. 3﹪,x2 =21. 484, P﹤0. 01) and diabetes mellitus (43. 1﹪ vs. 27. 7﹪,x2 =10. 737, P﹤0. 01). Men were more likely to be smokers. Female sex was associated with a higher unadjusted in-hospital mortality (8. 9﹪ vs. 4. 4﹪,x2 =3. 945, P=0. 047). After multivariable adjustment this sex difference disappeared (OR:1. 036, 95﹪CI: 0. 339 -3. 169, P =0. 95) . Conclusions Female sex is associated with an apparent hazard of increased mortality among patients undergoing primary PCI for STEMI, but this difference is likely explained by older age and worse baseline comorbidities among women.
