中国感染与化疗杂志
中國感染與化療雜誌
중국감염여화료잡지
CHINESE JOURNAL OF INFECTION AND CHEMOTHERAPY
2014年
6期
535-537
,共3页
复治肺结核%老年%结核分枝杆菌%耐药性
複治肺結覈%老年%結覈分枝桿菌%耐藥性
복치폐결핵%노년%결핵분지간균%내약성
recurrent pulmonary tuberculosis%elderly%Mycobacterium tuberculosis%drug resistance
目的:分析老年复治肺结核患者中分离的结核分枝杆菌(Mycobacterium tuberculosis)的耐药性。方法收集上海市肺科医院2005年1月至2013年12月1860例老年复治肺结核患者(复治组)分离菌株,对其进行耐药性分析。另选300例同期初治肺结核患者作为对照(初治组)。比较两组患者病原菌的耐药情况。结果复治组男性与女性患者中分离的病原菌对链霉素、利福平、乙胺丁醇、阿米卡星、卷曲霉素和氧氟沙星的耐药率比较,差异有统计学意义(均 P<0.05)。男性耐多药比率为24.0%(357/1489),广泛耐药比率为9.8%(146/1489);女性分别为34.2%(127/371),19.7%(73/371),差异有统计学意义( P<0.05)。复治组耐多药比率为26.0%(484/1860),广泛耐药比率为11.8%(219/1860);初治组分别为11.3%(34/300)和7.0%(21/300),差异有统计学意义( P<0.05)。复治组耐单药比率为20.0%(372/1860),初治组为41.0%(123/300),差异有统计学意义(P<0.05)。结论老年复治肺结核患者耐药率高,且女性患者耐药发生率高于男性;提示有必要加强老年复治肺结核耐药性监测。
目的:分析老年複治肺結覈患者中分離的結覈分枝桿菌(Mycobacterium tuberculosis)的耐藥性。方法收集上海市肺科醫院2005年1月至2013年12月1860例老年複治肺結覈患者(複治組)分離菌株,對其進行耐藥性分析。另選300例同期初治肺結覈患者作為對照(初治組)。比較兩組患者病原菌的耐藥情況。結果複治組男性與女性患者中分離的病原菌對鏈黴素、利福平、乙胺丁醇、阿米卡星、捲麯黴素和氧氟沙星的耐藥率比較,差異有統計學意義(均 P<0.05)。男性耐多藥比率為24.0%(357/1489),廣汎耐藥比率為9.8%(146/1489);女性分彆為34.2%(127/371),19.7%(73/371),差異有統計學意義( P<0.05)。複治組耐多藥比率為26.0%(484/1860),廣汎耐藥比率為11.8%(219/1860);初治組分彆為11.3%(34/300)和7.0%(21/300),差異有統計學意義( P<0.05)。複治組耐單藥比率為20.0%(372/1860),初治組為41.0%(123/300),差異有統計學意義(P<0.05)。結論老年複治肺結覈患者耐藥率高,且女性患者耐藥髮生率高于男性;提示有必要加彊老年複治肺結覈耐藥性鑑測。
목적:분석노년복치폐결핵환자중분리적결핵분지간균(Mycobacterium tuberculosis)적내약성。방법수집상해시폐과의원2005년1월지2013년12월1860례노년복치폐결핵환자(복치조)분리균주,대기진행내약성분석。령선300례동기초치폐결핵환자작위대조(초치조)。비교량조환자병원균적내약정황。결과복치조남성여녀성환자중분리적병원균대련매소、리복평、을알정순、아미잡성、권곡매소화양불사성적내약솔비교,차이유통계학의의(균 P<0.05)。남성내다약비솔위24.0%(357/1489),엄범내약비솔위9.8%(146/1489);녀성분별위34.2%(127/371),19.7%(73/371),차이유통계학의의( P<0.05)。복치조내다약비솔위26.0%(484/1860),엄범내약비솔위11.8%(219/1860);초치조분별위11.3%(34/300)화7.0%(21/300),차이유통계학의의( P<0.05)。복치조내단약비솔위20.0%(372/1860),초치조위41.0%(123/300),차이유통계학의의(P<0.05)。결론노년복치폐결핵환자내약솔고,차녀성환자내약발생솔고우남성;제시유필요가강노년복치폐결핵내약성감측。
Objective To analyze the drug resistance of Mycobacterium tuberculosis (MT) in elderly patients with recurrent pulmonary tuberculosis .Methods We collected 1 860 M T strains from elderly patients with recurrent pulmonary tuberculosis in our hospital from January 2005 to December 2013 to review the drug resistance profile of these strains .Another 300 patients with naive pulmonary tuberculosis were included as control group .Results Significant difference was found between the males and females in terms of the resistance rate to streptomycin ,rifampicin ,ethambutol ,amikacin ,capreomycin ,or ofloxacin (P<0 .05) .Multi‐drug resistant tuberculosis (MDR‐TB) was identified in 24 .0% (357/1 489) and extensively drug‐resistant tuberculosis (XDR‐TB) in 9 .8% (146/1 489) in male patients ,which were significantly lower than the corresponding rates of 34 .2% (127/371) and 19 .7% (73/371) in the female patients (P<0 .05) .In all the 1 860 patients with recurrent pulmonary tuberculosis , MDR‐TB and XDR‐TB accounted for 26 .0% and 11 .8% , respectively , significantly higher than the corresponding rates of 11 .3% (34/300) and 7 .0% (21/300) in the control patients with naive pulmonary tuberculosis .Single drug resistance was identified in 20 .0% (372/1 860) of the patients with recurrent tuberculosis and 41 .0% (123/300) of the control patients (P<0 .05) .Conclusions The MT strains isolated from elderly patients with recurrent pulmonary tuberculosis show higher resistance rate ,especially in females .It is necessary to strengthen the monitoring of drug resistance in old patients with recurrent pulmonary tuberculosis .