CAJ | 학술논문

研究芎汤活血有效部位给药大鼠体内的整体吸收规律。将活血有效部位给大鼠灌胃后，测绘不同时间点血浆的 HPLC 指纹图谱，通过比较计算特征峰欧式距离，研究该复方药对的吸收规律。芎汤活血有效部位大鼠给药后，45 min 药物吸收最高，1.5 h 之内体内药物浓度保持在较高水平，随后变化较小。采用指纹图谱技术测定复方给药后的血浆成分，能更好地反映中药多成分在体内的吸收规律。
연구궁탕활혈유효부위급약대서체내적정체흡수규률。장활혈유효부위급대서관위후，측회불동시간점혈장적 HPLC 지문도보，통과비교계산특정봉구식거리，연구해복방약대적흡수규률。궁탕활혈유효부위대서급약후，45 min 약물흡수최고，1.5 h 지내체내약물농도보지재교고수평，수후변화교소。채용지문도보기술측정복방급약후적혈장성분，능경호지반영중약다성분재체내적흡수규률。
The integrated absorption pattern of blood-activating part of Xiong-qiong decoction in rats was studied. The plasma samples of rats were collected according to different time points before and after oral administration with blood-activating part and the chemical component in those samples were determined by HPLC fingerprint. The euclidean distance was calculated according to the characteristic peak area of HPLC fingerprint and used as the integral index for the integrated absorption pattern of multi-components in Xiong-qiong decoction. It showed that the plasma concentration reached the highest level at 45 minutes and could be maintained at a certain level within one hour and a half. HPLC fingerfrint can be applied for the study of internal absorption pattern of Chinese medicine formula.