CAJ | 학술논문

目的：探讨生存素（Survivin）和黏蛋白2（mucin 2，MUC2）的表达与萎缩性胃炎伴肠化生及胃癌的关系。方法构建含30例正常胃黏膜、30例萎缩性胃炎伴肠化生和41例胃癌的组织芯片，用免疫组化方法（ S－P法）检测组织芯片中Survivin和MUC2的表达。结果 Survivin和MUC2表达阳性率在正常胃黏膜组织中为7．14％和0％；在萎缩性胃炎伴肠化生胃黏膜中为21．43％和75．00％；在胃癌中为77．78％和13．89％。二者在不同胃黏膜阳性表达率总体差异有显著性意义（P＜0．001）。胃癌组织中Survivin表达与Lauren分型、浸润深度、TNM分期有关（P＜0．05）。 MUC2表达与Lauren分型、分化程度有关（P＜0．05）。二者表达均与患者性别、年龄、淋巴结转移、病变部位、肿瘤大小无关（P＞0．05）。 Survivin与MUC2表达间无明显相关性（r＝0．215，P＝0．209）。结论 Sur－vivin和MUC2表达在胃黏膜肠化生及胃癌发生中发挥一定作用。
목적：탐토생존소（Survivin）화점단백2（mucin 2，MUC2）적표체여위축성위염반장화생급위암적관계。방법구건함30례정상위점막、30례위축성위염반장화생화41례위암적조직심편，용면역조화방법（ S－P법）검측조직심편중Survivin화MUC2적표체。결과 Survivin화MUC2표체양성솔재정상위점막조직중위7．14％화0％；재위축성위염반장화생위점막중위21．43％화75．00％；재위암중위77．78％화13．89％。이자재불동위점막양성표체솔총체차이유현저성의의（P＜0．001）。위암조직중Survivin표체여Lauren분형、침윤심도、TNM분기유관（P＜0．05）。 MUC2표체여Lauren분형、분화정도유관（P＜0．05）。이자표체균여환자성별、년령、림파결전이、병변부위、종류대소무관（P＞0．05）。 Survivin여MUC2표체간무명현상관성（r＝0．215，P＝0．209）。결론 Sur－vivin화MUC2표체재위점막장화생급위암발생중발휘일정작용。
Objective To investigate expression of Survivin and mucin 2( MUC2) ,and their correlation with atrophic gas-tritis with intestinal metaplasia and gastric carcinoma.Methods 30 normal gastric mucosa, 30 tissues with atrophic gastritis with intestinal metaplasia,41 tissues with gastric carcinoma were detected with immunohistochemistry.The expressions of survivin and MUC2 in tissue microarray were studied.Results Two normal gastric mucosa expressed Survivin(7.14%) ,but MUC2 was not expressed in the normal gastric mucosa.The positive expression rate of survivin was 21.43%and MUC2 was 75.00%in atrophic gastritis with intestinal metaplasia.The positive expression rate of Survivin was 77.78%, MUC2 was 13.89%in gastric carcinoma .The positive expression rate of Survivin and MUC2 in different gastric mucosa was of statisti-cal significance(P<0.001).The expression of Survivin in gastric carcinoma showed statistically significant difference(P<0.05)in different Lauren classification、depth of invasion and TNM categories.The expression of MUC2 in different Lauren classification,tumor differentiation was statistically significant difference(P<0.05).The expression of Survivin and MUC2 in gastric carcinoma was not associated with gender,patients age, lymph node metastasis, tumor location, tumor size( P>0.05).The expression of Survivin shows no obvious correlation with MUC2(r=0.215,P=0.209).Conclusion The ex-pressions of survivin and MUC2 might play an important role in the development of gastric carcinoma.