中华普通外科杂志
中華普通外科雜誌
중화보통외과잡지
CHINESE JOURNAL OF GENERAL SURGERY
2014年
11期
821-823
,共3页
季倩%褚志强%沈文%郑虹%祁吉
季倩%褚誌彊%瀋文%鄭虹%祁吉
계천%저지강%침문%정홍%기길
肝移植%活体供者%年龄因素%肝再生
肝移植%活體供者%年齡因素%肝再生
간이식%활체공자%년령인소%간재생
Liver transplantation%Living donors%Age factors%Liver regeneration
目的 评价供者年龄对成人活体右半肝移植(living donor liver transplantation,LDLT)术后早期残肝功能及再生的影响.方法 43例LDLT术后供者分为2组:年龄＞50岁为老年组,8例,年龄＜ 30岁为年轻组,35例,比较2组患者术后早期丙氨酸转氨酶(alanine aminotransferase,ALT)、天冬氨酸转氨酶(aspartate aminotransferase,AST)、总胆红素(total bilirubin,TB)及肝再生率(liver regenerative ratio,LRR).结果 术后1、2、3、5d老年组与年轻组ALT、AST和TB比较,差异均无统计学意义(分别t=0.147、1.030、-0.903、-0.013、0.043、1.362、0.817、0.003、1.121、0.241、1.061和0.943,均P＞0.05).术后7d年轻组LRR明显高于老年组,差异有统计学意义(t=-0.965,P=0.042);术后15d2组差异无统计学意义(t=0.585,P=0.385).结论 LDLT老年供肝者术后7d内残肝再生迟缓,但供者年龄对术后7d以内残肝功能恢复无显著影响.
目的 評價供者年齡對成人活體右半肝移植(living donor liver transplantation,LDLT)術後早期殘肝功能及再生的影響.方法 43例LDLT術後供者分為2組:年齡＞50歲為老年組,8例,年齡＜ 30歲為年輕組,35例,比較2組患者術後早期丙氨痠轉氨酶(alanine aminotransferase,ALT)、天鼕氨痠轉氨酶(aspartate aminotransferase,AST)、總膽紅素(total bilirubin,TB)及肝再生率(liver regenerative ratio,LRR).結果 術後1、2、3、5d老年組與年輕組ALT、AST和TB比較,差異均無統計學意義(分彆t=0.147、1.030、-0.903、-0.013、0.043、1.362、0.817、0.003、1.121、0.241、1.061和0.943,均P＞0.05).術後7d年輕組LRR明顯高于老年組,差異有統計學意義(t=-0.965,P=0.042);術後15d2組差異無統計學意義(t=0.585,P=0.385).結論 LDLT老年供肝者術後7d內殘肝再生遲緩,但供者年齡對術後7d以內殘肝功能恢複無顯著影響.
목적 평개공자년령대성인활체우반간이식(living donor liver transplantation,LDLT)술후조기잔간공능급재생적영향.방법 43례LDLT술후공자분위2조:년령＞50세위노년조,8례,년령＜ 30세위년경조,35례,비교2조환자술후조기병안산전안매(alanine aminotransferase,ALT)、천동안산전안매(aspartate aminotransferase,AST)、총담홍소(total bilirubin,TB)급간재생솔(liver regenerative ratio,LRR).결과 술후1、2、3、5d노년조여년경조ALT、AST화TB비교,차이균무통계학의의(분별t=0.147、1.030、-0.903、-0.013、0.043、1.362、0.817、0.003、1.121、0.241、1.061화0.943,균P＞0.05).술후7d년경조LRR명현고우노년조,차이유통계학의의(t=-0.965,P=0.042);술후15d2조차이무통계학의의(t=0.585,P=0.385).결론 LDLT노년공간자술후7d내잔간재생지완,단공자년령대술후7d이내잔간공능회복무현저영향.
Objective To evaluate the impact of donor age on early remnant liver function and regeneration after right lobe adult living donor liver transplantation (LDLT) donation.Methods 43 living donors were divided into 2 groups:donor age ＞ 50,n =8,and donor age ＜ 30,n =35.Alanine aminotransferase (ALT),aspartate aminotransferase (AST),total bilirubin (TB) and liver regenerative ratio (LRR) of donors between the 2 groups were compared.Results There were no significantly different in ALT,AST and TB on days 1,2,3,5 after LDLT between the 2 groups (respectively t =0.147,1.030,-0.903,0.013,0.043,1.362,0.817,0.003,1.121,0.241,1.061 and 0.943,all P＞0.05).There was significant difference between LRR on day 7 (t =-0.965,P =0.042),but the difference was not statistically significant in LRR when evaluated on day 15 after LDLT (t =0.585,P =0.385).Conclusions Remnant liver regeneration on the first week is reversely affected by donor's age after hepatectomy,while the influence of age decreases significantly after 2 weeks.
