中华普通外科杂志
中華普通外科雜誌
중화보통외과잡지
CHINESE JOURNAL OF GENERAL SURGERY
2014年
12期
934-936
,共3页
翟薇%李玫%董建强%郁卫东
翟薇%李玫%董建彊%鬱衛東
적미%리매%동건강%욱위동
胃肿瘤%磷酸肌醇3-激酶类%预后
胃腫瘤%燐痠肌醇3-激酶類%預後
위종류%린산기순3-격매류%예후
Stomach neoplasms%Phosphatidylinositol 3-kinases%Prognosis
目的 明确磷脂酰肌醇-3激酶催化亚基β(phosphoinositide-3 kinase,catalytic subunit beta,PIK3CB)在胃癌组织中的表达,探讨其在胃癌发生发展中的临床意义.方法 应用组织芯片和免疫组织化学技术,检测PIK3CB蛋白在138例胃腺癌组织中的表达,并对PIK3 CB表达与胃癌患者的临床病理特点和预后进行分析.结果 PIK3CB在胃癌组织中阳性表达率为63.8％,癌旁组织中阳性表达率为45.7％,两者相比差异有统计学意义(x2=9.139,P=0.003);PIK3CB高表达与胃癌大小(x2 =8.677,P =0.003)、胃癌浸润深度(x2=9.306,P=0.025)和临床分期(x2=8.242,P=0.041)相关;高表达和低表达PIK3 CB的胃癌患者术后5年累积生存率分别为15.9％和70.3％,中位生存时间分别为30.2个月和60.3个月,差异有统计学意义(x2=25.644,P=0.000).多因素分析显示,PIK3 CB可作为一个独立的预后评估因素(HR=15.785,95％CI:1.943～7.805,P=0.000).结论 PIK3CB表达上调与胃癌的浸润程度和患者的生存时间相关,可看成是评估胃癌预后的一个独立影响因素.
目的 明確燐脂酰肌醇-3激酶催化亞基β(phosphoinositide-3 kinase,catalytic subunit beta,PIK3CB)在胃癌組織中的錶達,探討其在胃癌髮生髮展中的臨床意義.方法 應用組織芯片和免疫組織化學技術,檢測PIK3CB蛋白在138例胃腺癌組織中的錶達,併對PIK3 CB錶達與胃癌患者的臨床病理特點和預後進行分析.結果 PIK3CB在胃癌組織中暘性錶達率為63.8％,癌徬組織中暘性錶達率為45.7％,兩者相比差異有統計學意義(x2=9.139,P=0.003);PIK3CB高錶達與胃癌大小(x2 =8.677,P =0.003)、胃癌浸潤深度(x2=9.306,P=0.025)和臨床分期(x2=8.242,P=0.041)相關;高錶達和低錶達PIK3 CB的胃癌患者術後5年纍積生存率分彆為15.9％和70.3％,中位生存時間分彆為30.2箇月和60.3箇月,差異有統計學意義(x2=25.644,P=0.000).多因素分析顯示,PIK3 CB可作為一箇獨立的預後評估因素(HR=15.785,95％CI:1.943～7.805,P=0.000).結論 PIK3CB錶達上調與胃癌的浸潤程度和患者的生存時間相關,可看成是評估胃癌預後的一箇獨立影響因素.
목적 명학린지선기순-3격매최화아기β(phosphoinositide-3 kinase,catalytic subunit beta,PIK3CB)재위암조직중적표체,탐토기재위암발생발전중적림상의의.방법 응용조직심편화면역조직화학기술,검측PIK3CB단백재138례위선암조직중적표체,병대PIK3 CB표체여위암환자적림상병리특점화예후진행분석.결과 PIK3CB재위암조직중양성표체솔위63.8％,암방조직중양성표체솔위45.7％,량자상비차이유통계학의의(x2=9.139,P=0.003);PIK3CB고표체여위암대소(x2 =8.677,P =0.003)、위암침윤심도(x2=9.306,P=0.025)화림상분기(x2=8.242,P=0.041)상관;고표체화저표체PIK3 CB적위암환자술후5년루적생존솔분별위15.9％화70.3％,중위생존시간분별위30.2개월화60.3개월,차이유통계학의의(x2=25.644,P=0.000).다인소분석현시,PIK3 CB가작위일개독립적예후평고인소(HR=15.785,95％CI:1.943～7.805,P=0.000).결론 PIK3CB표체상조여위암적침윤정도화환자적생존시간상관,가간성시평고위암예후적일개독립영향인소.
Objective To analyze the correlation between the expression of phosphoinositide-3 kinase,catalytic subunit beta (PIK3CB) and the clinicopathologic characteristics in gastric adenocarcinoma tissues.Methods Immunohistochemistry was used to determine PIK3CB expression in human gastric adenocarcinoma tissues and matched adjacent tissues.The correlation between PIK3CB expression and the patients' clinicopathological characteristics and prognosis was statistically analyzed.Results PIK3CB is highly expressed in gastric adenocarcinoma tissues (positive rate 63.8％) compared with matched adjacent tissues (positive rate 45.7％) (x2 =9.139,P =0.003).PIK3CB expression is significantly correlated with tumor size (x2 =8.677,P =0.003),infiltration (x2 =9.306,P =0.025),and clinical stage (x2 =8.242,P =0.041) ; Level of PIK3CB expression has a significant impact on prognosis (x2 =25.644,P =0.000).Multivariate analyses showed that high PIK3CB expression is an independent poor prognostic factor for overall survival (HR =15.785,95％ CI:1.943-7.805,P =0.000).Conclusions Upregulated PIK3CB is correlated with poor postoperative prognosis of gastric carcinoma.
